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Agt Gene Detail
Summary
  • Symbol
    Agt
  • Name
    angiotensinogen
  • Synonyms
    angiotensin precursor, Aogen, Serpina8
  • Feature Type
    protein coding gene
  • IDs
    MGI:87963
    NCBI Gene: 11606
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125283326-125296445 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87963
 protein coding gene Chr8:125283273-125296445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034272
 protein coding gene Chr8:128245438-128260823 (-)
A/J MGP_AJ_G0034252
 protein coding gene Chr8:122939198-122952182 (-)
AKR/J MGP_AKRJ_G0034179
 protein coding gene Chr8:126469592-126488387 (-)
BALB/cJ MGP_BALBcJ_G0034245
 protein coding gene Chr8:123124486-123138317 (-)
C3H/HeJ MGP_C3HHeJ_G0033956
 protein coding gene Chr8:127120070-127136555 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034765
 protein coding gene Chr8:132535664-132548855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031706
 protein coding gene Chr8:115708688-115721570 (-)
CAST/EiJ MGP_CASTEiJ_G0033283
 protein coding gene Chr8:127236714-127250973 (-)
CBA/J MGP_CBAJ_G0033929
 protein coding gene Chr8:137396367-137412818 (-)
DBA/2J MGP_DBA2J_G0034085
 protein coding gene Chr8:122096196-122109344 (-)
FVB/NJ MGP_FVBNJ_G0034029
 protein coding gene Chr8:121267798-121281960 (-)
LP/J MGP_LPJ_G0034174
 protein coding gene Chr8:128401374-128414393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034076
 protein coding gene Chr8:139479234-139492297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034784
 protein coding gene Chr8:126710217-126723243 (-)
PWK/PhJ MGP_PWKPhJ_G0032985
 protein coding gene Chr8:121860106-121873269 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032824
 protein coding gene Chr8:125350926-125366646 (-)
WSB/EiJ MGP_WSBEiJ_G0033400
 protein coding gene Chr8:127431587-127444652 (-)



Homology
more
  • Human Ortholog
    AGT, angiotensinogen
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGT, angiotensinogen
  • Synonyms
    ANHU, hFLT1, SERPINA8
  • Links
    NCBI Gene ID: 183
    neXtProt AC: NX_P01019
    UniProt: P01019

  • Chr Location
    1q42.2; chr1:230690776-230745583 (-)  GRCh38
Human Diseases
more
  • Diseases
    21 with human AGT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
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IDs
IDs
IDs
IDs
IDs
IDs
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IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 4 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    153
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    75
  • cDNA Data
    144
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11606 NCBI Gene Model | MGI Sequence Detail 13120 C57BL/6J ±  kb
    transcript NM_001416312 RefSeq | MGI Sequence Detail 1900 ZRU/MplStud  
    polypeptide P11859 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      Genomic 10
      cDNA 146
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1192, MGI:2142488
    References
    more
    • Summaries
      All 257
      Developmental Gene Expression 24
      Gene Ontology 34
      Phenotypes 74
    • Earliest
      J:9259 Clouston WM, et al., Molecular cloning of the mouse angiotensinogen gene. Genomics. 1988 Apr;2(3):240-8
    • Latest
      J:354069 Bode M, et al., Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage. Hypertension. 2024 Jan;81(1):138-150
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory