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Akp3 Gene Detail
Summary
  • Symbol
    Akp3
  • Name
    alkaline phosphatase 3, intestine, not Mn requiring
  • Synonyms
    Akp-3, IAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87984
    NCBI Gene: 11648
  • Alliance
  • Transcription Start Sites
    31 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:87052695-87055634 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.06 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87984
protein coding gene Chr1:87052676-87056450 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016256
protein coding gene Chr1:88459503-88462442 (+)
A/J MGP_AJ_G0016237
protein coding gene Chr1:85156833-85159772 (+)
AKR/J MGP_AKRJ_G0016198
protein coding gene Chr1:87670403-87673342 (+)
BALB/cJ MGP_BALBcJ_G0016194
protein coding gene Chr1:85277316-85280255 (+)
C3H/HeJ MGP_C3HHeJ_G0016022
protein coding gene Chr1:87932624-87935563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016650
protein coding gene Chr1:91807480-91810419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014372
protein coding gene Chr1:79611238-79614410 (+)
CAST/EiJ MGP_CASTEiJ_G0015607
protein coding gene Chr1:87135749-87140247 (+)
CBA/J MGP_CBAJ_G0015998
protein coding gene Chr1:94672952-94675891 (+)
DBA/2J MGP_DBA2J_G0016101
protein coding gene Chr1:84461238-84464177 (+)
FVB/NJ MGP_FVBNJ_G0016100
protein coding gene Chr1:83524039-83526978 (+)
LP/J MGP_LPJ_G0016172
protein coding gene Chr1:89526695-89534073 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016126
protein coding gene Chr1:97957052-97960026 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016693
protein coding gene Chr1:87772746-87775685 (+)
PWK/PhJ MGP_PWKPhJ_G0015394
protein coding gene Chr1:83758539-83761500 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015174
protein coding gene Chr1:86699607-86702551 (+)
WSB/EiJ MGP_WSBEiJ_G0015671
protein coding gene Chr1:87439497-87442424 (+)



Homology
more
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Synonyms
    ALPPL, ALPPL2, GCAP
  • Links
    NCBI Gene ID: 251
    neXtProt AC: NX_P10696
    UniProt: P10696

  • Chr Location
    2q37.1; chr2:232406844-232410714 (+)  GRCh38

  • Human Ortholog
    ALPI, alkaline phosphatase, intestinal
  • Synonyms
    IAP
  • Links
    NCBI Gene ID: 248
    neXtProt AC: NX_P09923
    UniProt: P09923

  • Chr Location
    2q37.1; chr2:232456125-232460753 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human ALPI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene show no gross abnormalities in appearance, behavior or fertility. They do display accelerated lipid absorption on a high fat diet leading to elevated plasma triglycerides and increased weight gain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036500 Ensembl Gene Model | MGI Sequence Detail 2940 C57BL/6J ±  kb
    transcript ENSMUST00000044878 Ensembl | MGI Sequence Detail 1680 Not Applicable  
    polypeptide ENSMUSP00000037497 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR001952 Alkaline phosphatase
      IPR018299 Alkaline phosphatase, active site
      IPR017850 Alkaline-phosphatase-like, core domain superfamily
    • GlyGen
      P24822 3 sites
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 3
      cDNA 7
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1250, MGD-MRK-1255
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:322077 Liu Y, et al., A role for intestinal alkaline phosphatase in preventing liver fibrosis. Theranostics. 2021;11(1):14-26

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory