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Akt1 Gene Detail
Summary
  • Symbol
    Akt1
  • Name
    thymoma viral proto-oncogene 1
  • Synonyms
    Akt, PKB, PKB/Akt, PKBalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:87986
    NCBI Gene: 11651
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:112620260-112641266 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.20 cM, cytoband F1-F2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    637 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87986
 protein coding gene Chr12:112620255-112641318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020156
 protein coding gene Chr12:115114616-115141241 (-)
A/J MGP_AJ_G0020112
 protein coding gene Chr12:110683780-110704753 (-)
AKR/J MGP_AKRJ_G0020087
 protein coding gene Chr12:113872922-113893896 (-)
BALB/cJ MGP_BALBcJ_G0020097
 protein coding gene Chr12:111127083-111149115 (-)
C3H/HeJ MGP_C3HHeJ_G0019899
 protein coding gene Chr12:114382615-114403436 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020542
 protein coding gene Chr12:118681146-118702122 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018156
 protein coding gene Chr12:107114451-107135509 (-)
CAST/EiJ MGP_CASTEiJ_G0019439
 protein coding gene Chr12:109229154-109251009 (-)
CBA/J MGP_CBAJ_G0019866
 protein coding gene Chr12:123217354-123238113 (-)
DBA/2J MGP_DBA2J_G0019983
 protein coding gene Chr12:110162015-110183673 (-)
FVB/NJ MGP_FVBNJ_G0019968
 protein coding gene Chr12:108988515-109009726 (-)
LP/J MGP_LPJ_G0020057
 protein coding gene Chr12:114946634-114971114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020006
 protein coding gene Chr12:126301172-126323438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020571
 protein coding gene Chr12:113395524-113418825 (-)
PWK/PhJ MGP_PWKPhJ_G0019201
 protein coding gene Chr12:104819850-104841969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019005
 protein coding gene Chr12:107560422-107581389 (-)
WSB/EiJ MGP_WSBEiJ_G0019499
 protein coding gene Chr12:114304958-114325721 (-)



Homology
more
  • Human Ortholog
    AKT1, AKT serine/threonine kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKT1, AKT serine/threonine kinase 1
  • Synonyms
    AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
  • Links
    NCBI Gene ID: 207
    neXtProt AC: NX_P31749
    UniProt: P31749

  • Chr Location
    14q32.33; chr14:104769349-104795759 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Akt1 mouse models; 18 with human AKT1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 12 alleles in 13 genetic backgrounds
    41 phenotypes from multigenic genotypes
    3 images
    252 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes are smaller than sibs due to retarded prenatal and postnatal growth and exhibit increased apoptosis and decreased lifespan with genotoxic stress. Mice are fertile, but males have attenuated spermatogenesis and abnormal testes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    323
  • GO References
    95
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1591
  • Tissues
    212
  • cDNA Data
    222
  • Literature Summary
    391
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11651 NCBI Gene Model | MGI Sequence Detail 21007 C57BL/6J ±  kb
    transcript NR_176839 RefSeq | MGI Sequence Detail 2660 ZRU/MplStud  
    polypeptide P31750 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 234
      Genomic 2
      cDNA 222
      Primer pair 9
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1257
    References
    more
    • Summaries
      All 1328
      Developmental Gene Expression 391
      Diseases 3
      Gene Ontology 95
      Phenotypes 252
    • Earliest
      J:455 Cho M, et al., A linkage map of distal mouse chromosome 12. Mamm Genome. 1991;1(1):30-6
    • Latest
      J:354208 Dong MZ, et al., Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory