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Alb Gene Detail
Summary
  • Symbol
    Alb
  • Name
    albumin
  • Synonyms
    Alb-1, Alb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87991
    NCBI Gene: 11657
  • Alliance
    gene page
  • Transcription Start Sites
    49 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90608756-90624461 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.70 cM
  • Mapping Data
    41 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87991
 protein coding gene Chr5:90608729-90624461 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029721
 protein coding gene Chr5:91540813-91556763 (+)
A/J MGP_AJ_G0029687
 protein coding gene Chr5:87918598-87934584 (+)
AKR/J MGP_AKRJ_G0029633
 protein coding gene Chr5:90785367-90801431 (+)
BALB/cJ MGP_BALBcJ_G0029697
 protein coding gene Chr5:88818345-88833377 (+)
C3H/HeJ MGP_C3HHeJ_G0029420
 protein coding gene Chr5:91201973-91218807 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030151
 protein coding gene Chr5:95203124-95219593 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027387
 protein coding gene Chr5:83648626-83663329 (+)
CAST/EiJ MGP_CASTEiJ_G0028830
 protein coding gene Chr5:90566855-90582261 (+)
CBA/J MGP_CBAJ_G0029390
 protein coding gene Chr5:98455375-98470357 (+)
DBA/2J MGP_DBA2J_G0029534
 protein coding gene Chr5:88002415-88017428 (+)
FVB/NJ MGP_FVBNJ_G0029493
 protein coding gene Chr5:86862446-86877380 (+)
LP/J MGP_LPJ_G0029622
 protein coding gene Chr5:91921356-91936472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029522
 protein coding gene Chr5:103461553-103477922 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030185
 protein coding gene Chr5:90318060-90333898 (+)
PWK/PhJ MGP_PWKPhJ_G0028549
 protein coding gene Chr5:87058822-87073783 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028384
 protein coding gene Chr5:89723016-89737689 (+)
WSB/EiJ MGP_WSBEiJ_G0028909
 protein coding gene Chr5:90778540-90794762 (+)



Homology
more
  • Human Ortholog
    ALB, albumin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALB, albumin
  • Synonyms
    FDAHT, HSA, PRO0883, PRO0903, PRO1341
  • Links
    NCBI Gene ID: 213
    neXtProt AC: NX_P02768
    UniProt: P02768

  • Chr Location
    4q13.3; chr4:73397114-73421482 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human ALB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    81 phenotypes from multigenic genotypes
    2 images
    155 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a TALEN-mediated deletion exhibit analbuminemia but appear healthy and grossly normal and breed normally. Mice heterozygotes for an ENU-induced point mutation have significantly reduced plasma albumin and calcium levels and significantly elevated alkaline phosphatase activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1068
  • Tissues
    77
  • cDNA Data
    3005
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029368 Ensembl Gene Model | MGI Sequence Detail 15706 C57BL/6J ±  kb
    transcript ENSMUST00000031314 Ensembl | MGI Sequence Detail 2034 Not Applicable  
    polypeptide ENSMUSP00000031314 Ensembl | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3052
      Genomic 19
      cDNA 3009
      Primer pair 19
      Other 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1272, MGD-MRK-1273, MGI:5425960
    References
    more
    • Summaries
      All 362
      Developmental Gene Expression 109
      Diseases 1
      Gene Ontology 14
      Phenotypes 155
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory