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Alox5 Gene Detail
Summary
  • Symbol
    Alox5
  • Name
    arachidonate 5-lipoxygenase
  • Synonyms
    5-LO, 5LO, 5-LOX, 5LX
  • Feature Type
    protein coding gene
  • IDs
    MGI:87999
    NCBI Gene: 11689
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:116387038-116438139 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.79 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1625 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87999
 protein coding gene Chr6:116387030-116438139 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031167
 protein coding gene Chr6:119083542-119138318 (-)
A/J MGP_AJ_G0031137
 protein coding gene Chr6:114511167-114565530 (-)
AKR/J MGP_AKRJ_G0031067
 protein coding gene Chr6:117568965-117622841 (-)
BALB/cJ MGP_BALBcJ_G0031147
 protein coding gene Chr6:114321432-114372958 (-)
C3H/HeJ MGP_C3HHeJ_G0030561
 protein coding gene Chr6:66666704-66720138 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031606
 protein coding gene Chr6:122152332-122202494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028770
 protein coding gene Chr6:111510826-111558593 (-)
CAST/EiJ MGP_CASTEiJ_G0030254
 protein coding gene Chr6:117966824-118018590 (-)
CBA/J MGP_CBAJ_G0030833
 protein coding gene Chr6:126924831-126989100 (-)
DBA/2J MGP_DBA2J_G0030987
 protein coding gene Chr6:113425674-113476617 (-)
FVB/NJ MGP_FVBNJ_G0030940
 protein coding gene Chr6:112621374-112671971 (-)
LP/J MGP_LPJ_G0031066
 protein coding gene Chr6:119091374-119146049 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030975
 protein coding gene Chr6:131068755-131133598 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031634
 protein coding gene Chr6:117613858-117666694 (-)
PWK/PhJ MGP_PWKPhJ_G0029970
 protein coding gene Chr6:112444048-112495702 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029798
 protein coding gene Chr6:116356968-116408128 (-)
WSB/EiJ MGP_WSBEiJ_G0030338
 protein coding gene Chr6:117885450-117940077 (-)



Homology
more
  • Human Ortholog
    ALOX5, arachidonate 5-lipoxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALOX5, arachidonate 5-lipoxygenase
  • Synonyms
    5-LO, 5-LOX, 5LPG, LOG5
  • Links
    NCBI Gene ID: 240
    neXtProt AC: NX_P09917
    UniProt: P09917

  • Chr Location
    10q11.21; chr10:45374176-45446119 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human ALOX5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show altered inflammatory responses. One null mutation causes resistance to lethal anaphylaxis, abnormal eicosanoid production and neutrophil recruitment while another leads to increased body fat, bone density, leptin and VLDL cholesterol levels and resistance to autoimmune uveitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    102
  • cDNA Data
    34
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025701 Ensembl Gene Model | MGI Sequence Detail 51102 C57BL/6J ±  kb
    transcript ENSMUST00000026795 Ensembl | MGI Sequence Detail 2821 Not Applicable  
    polypeptide ENSMUSP00000026795 Ensembl | MGI Sequence Detail 674 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 34
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1286, MGI:2141502
    References
    more
    • Summaries
      All 236
      Developmental Gene Expression 7
      Gene Ontology 26
      Phenotypes 158
    • Earliest
      J:19332 Funk CD, et al., Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions. Ann N Y Acad Sci. 1994 Apr 18;714:253-8
    • Latest
      J:353731 Mihlan M, et al., Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay. Cell. 2024 Jul 27;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory