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Ank3 Gene Detail
Summary
  • Symbol
    Ank3
  • Name
    ankyrin 3, epithelial
  • Synonyms
    2900054D09Rik, Ank-3, AnkG, Ankyrin-3, Ankyrin-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:88026
    NCBI Gene: 11735
  • Alliance
    gene page
  • Transcription Start Sites
    54 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:69234608-69863266 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 36.10 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19123 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88026
 protein coding gene Chr10:69234603-69863268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017335
 protein coding gene Chr10:69412452-69929867 (+)
A/J MGP_AJ_G0017312
 protein coding gene Chr10:67063292-67561812 (+)
AKR/J MGP_AKRJ_G0017273
 protein coding gene Chr10:68884054-69399178 (+)
BALB/cJ MGP_BALBcJ_G0017272
 protein coding gene Chr10:67256881-67762247 (+)
C3H/HeJ MGP_C3HHeJ_G0017096
 protein coding gene Chr10:68898586-69417236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017730
 protein coding gene Chr10:71911312-72461924 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015420
 protein coding gene Chr10:63694135-64179718 (+)
CAST/EiJ MGP_CASTEiJ_G0016666
 protein coding gene Chr10:69000725-69539135 (+)
CBA/J MGP_CBAJ_G0017068
 protein coding gene Chr10:74664201-75223411 (+)
DBA/2J MGP_DBA2J_G0017173
 protein coding gene Chr10:66420860-66920809 (+)
FVB/NJ MGP_FVBNJ_G0017166
 protein coding gene Chr10:65586796-66092252 (+)
LP/J MGP_LPJ_G0017246
 protein coding gene Chr10:69827435-70373970 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017194
 protein coding gene Chr10:76825654-77367892 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017769
 protein coding gene Chr10:68823917-69344640 (+)
PWK/PhJ MGP_PWKPhJ_G0016450
 protein coding gene Chr10:66251485-66763869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016232
 protein coding gene Chr10:68197419-68726118 (+)
WSB/EiJ MGP_WSBEiJ_G0016730
 protein coding gene Chr10:68748074-69275340 (+)



Homology
more
  • Human Ortholog
    ANK3, ankyrin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANK3, ankyrin 3
  • Synonyms
    ANKYRIN-G, MRT37
  • Links
    NCBI Gene ID: 288
    neXtProt AC: NX_Q12955
    UniProt: Q12955

  • Chr Location
    10q21.2; chr10:60026298-60733528 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ANK3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 5 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a mutation that selectively ablates gene expression in brain exhibit progressive ataxia, tremors, and a substantially reduced cerebellum deficient in Purkinje cells. Mutants are poor breeders and die by 4-6 months.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    42
  • cDNA Data
    148
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11735 NCBI Gene Model | MGI Sequence Detail 628659 C57BL/6J ±  kb
    transcript NM_146005 RefSeq | MGI Sequence Detail 10025 ZRU/MplStud  
    polypeptide G5E8K5 UniProt | EBI | MGI Sequence Detail 1961 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 164
      cDNA 157
      Primer pair 7

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-1326, MGD-MRK-1329, MGI:1920263, MGI:2143560
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 30
      Gene Ontology 24
      Phenotypes 51
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:357972 Melton AJ, et al., TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation. J Neurosci. 2024 Oct 16;44(42)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory