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Prdx3 Gene Detail
Summary
  • Symbol
    Prdx3
  • Name
    peroxiredoxin 3
  • Synonyms
    Aop1, D0Tohi1, Ef2l, Mer5, Prx III, SP22, TDXM
  • Feature Type
    protein coding gene
  • IDs
    MGI:88034
    NCBI Gene: 11757
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:60852504-60862976 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 56.52 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88034
 protein coding gene Chr19:60852489-60862994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025298
 protein coding gene Chr19:61475885-61488674 (-)
A/J MGP_AJ_G0025274
 protein coding gene Chr19:58470606-58482142 (-)
AKR/J MGP_AKRJ_G0025243
 protein coding gene Chr19:60299354-60313973 (-)
BALB/cJ MGP_BALBcJ_G0025269
 protein coding gene Chr19:58555348-58565745 (-)
C3H/HeJ MGP_C3HHeJ_G0025029
 protein coding gene Chr19:60541832-60552039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025712
 protein coding gene Chr19:62930765-62941195 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023124
 protein coding gene Chr19:57296103-57306477 (-)
CAST/EiJ MGP_CASTEiJ_G0024494
 protein coding gene Chr19:60643899-60656283 (-)
CBA/J MGP_CBAJ_G0025009
 protein coding gene Chr19:65995174-66006094 (-)
DBA/2J MGP_DBA2J_G0025141
 protein coding gene Chr19:58259234-58269660 (-)
FVB/NJ MGP_FVBNJ_G0025102
 protein coding gene Chr19:57923695-57935147 (-)
LP/J MGP_LPJ_G0025227
 protein coding gene Chr19:61307446-61319862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025135
 protein coding gene Chr19:65187463-65200293 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025770
 protein coding gene Chr19:60537620-60548657 (-)
PWK/PhJ MGP_PWKPhJ_G0024242
 protein coding gene Chr19:58197830-58208836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024045
 protein coding gene Chr19:59191162-59200161 (-)
WSB/EiJ MGP_WSBEiJ_G0024564
 protein coding gene Chr19:60646118-60658218 (-)



Homology
more
  • Human Ortholog
    PRDX3, peroxiredoxin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDX3, peroxiredoxin 3
  • Synonyms
    AOP-1, AOP1, HBC189, MER5, PPPCD, PRO1748, prx-III, SCAR32, SP-22
  • Links
    NCBI Gene ID: 10935
    neXtProt AC: NX_P30048
    UniProt: P30048

  • Chr Location
    10q26.11; chr10:119167720-119178812 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDX3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased fat mass, adipocyte hypertrophy, mitochondrial dysfunction, oxidative stress, adipokine dysregulation and altered lipid and glucose metabolism. Homozygotes for a gene-trap allele show reduced weight and high susceptibility to LPS-induced oxidative stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    158
  • cDNA Data
    164
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11757 NCBI Gene Model | MGI Sequence Detail 10473 C57BL/6J ±  kb
    transcript NM_007452 RefSeq | MGI Sequence Detail 1445 ZRU/MplStud  
    polypeptide P20108 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000013193 thioredoxin-dependent peroxide reductase, mitochondrial
      (term hierarchy)
    • EC
      1.11.1.24
    • InterPro Domains
      IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
      IPR019479 Peroxiredoxin, C-terminal
      IPR050217 Thiol-specific antioxidant peroxiredoxin
      IPR013766 Thioredoxin domain
      IPR036249 Thioredoxin-like superfamily
    • GlyGen
      P20108 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 167
      Genomic 1
      cDNA 164
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1339, MGD-MRK-2429, MGD-MRK-9312, MGI:2147761
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 17
    • Earliest
      J:10114 Yamamoto T, et al., Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells. Gene. 1989 Aug 15;80(2):337-43
    • Latest
      J:345131 Schraps N, et al., Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction. Free Radic Biol Med. 2024 Jan 22;213:248-265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory