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Apoc3 Gene Detail
Summary
  • Symbol
    Apoc3
  • Name
    apolipoprotein C-III
  • Feature Type
    protein coding gene
  • IDs
    MGI:88055
    NCBI Gene: 11814
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46144348-46146934 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88055
 protein coding gene Chr9:46144231-46146934 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034749
 protein coding gene Chr9:44863037-44867006 (-)
A/J MGP_AJ_G0034730
 protein coding gene Chr9:43578727-43581485 (-)
AKR/J MGP_AKRJ_G0034657
 protein coding gene Chr9:44466896-44469627 (-)
BALB/cJ MGP_BALBcJ_G0034721
 protein coding gene Chr9:43300238-43302908 (-)
C3H/HeJ MGP_C3HHeJ_G0034432
 protein coding gene Chr9:44940961-44943631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035242
 protein coding gene Chr9:46143798-46146471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032156
 protein coding gene Chr9:43109265-43111941 (-)
CAST/EiJ MGP_CASTEiJ_G0033754
 protein coding gene Chr9:44799050-44803658 (-)
CBA/J MGP_CBAJ_G0034404
 protein coding gene Chr9:47829041-47831728 (-)
DBA/2J MGP_DBA2J_G0034563
 protein coding gene Chr9:43450011-43452720 (-)
FVB/NJ MGP_FVBNJ_G0034504
 protein coding gene Chr9:42713766-42716438 (-)
LP/J MGP_LPJ_G0034644
 protein coding gene Chr9:45181558-45184229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034548
 protein coding gene Chr9:49577709-49580397 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035263
 protein coding gene Chr9:44386016-44388720 (-)
PWK/PhJ MGP_PWKPhJ_G0033459
 protein coding gene Chr9:43369005-43371757 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033295
 protein coding gene Chr9:44714638-44717327 (-)
WSB/EiJ MGP_WSBEiJ_G0033867
 protein coding gene Chr9:44435012-44437693 (-)



Homology
more
  • Human Ortholog
    APOC3, apolipoprotein C3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOC3, apolipoprotein C3
  • Synonyms
    Apo-C3, ApoC-3, APOCIII
  • Links
    NCBI Gene ID: 345
    neXtProt AC: NX_P02656
    UniProt: P02656

  • Chr Location
    11q23.3; chr11:116829706-116833072 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human APOC3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced fasted triglyceride levels, increased triglyceride secretion rate, and loss of postprandial and obesity-associated hypertriglyceridemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    150
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11814 NCBI Gene Model | MGI Sequence Detail 2587 C57BL/6J ±  kb
    transcript NM_001289755 RefSeq | MGI Sequence Detail 631 C57BL/6  
    polypeptide P33622 UniProt | EBI | MGI Sequence Detail 99 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      Genomic 3
      cDNA 150

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1371, MGD-MRK-1374
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
    • Latest
      J:341857 Hu X, et al., Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells. Metabolism. 2021 Jul;120:154800
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory