Apod MGI Mouse Gene Detail - MGI:88056

Symbol

Apod
Name

apolipoprotein D

Feature Type

protein coding gene
IDs

MGI:88056
NCBI Gene: 11815
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr16:31115010-31133626 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 21.41 cM
Mapping Data

11 experiments

SNPs within 2kb

551 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88056	protein coding gene	Chr16:31115010-31133626 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022719	protein coding gene	Chr16:29253496-29273673 (-)
A/J	MGP_AJ_G0022682	protein coding gene	Chr16:27897758-27916327 (-)
AKR/J	MGP_AKRJ_G0022656	protein coding gene	Chr16:28960505-28979081 (-)
BALB/cJ	MGP_BALBcJ_G0022686	protein coding gene	Chr16:28074825-28093585 (-)
C3H/HeJ	MGP_C3HHeJ_G0022451	protein coding gene	Chr16:29054210-29073871 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023135	protein coding gene	Chr16:29893677-29912339 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020653	protein coding gene	Chr16:28316440-28337835 (-)
CAST/EiJ	MGP_CASTEiJ_G0021979	protein coding gene	Chr16:29172475-29193087 (-)
CBA/J	MGP_CBAJ_G0022421	protein coding gene	Chr16:31142522-31161698 (-)
DBA/2J	MGP_DBA2J_G0022554	protein coding gene	Chr16:27775732-27794308 (-)
FVB/NJ	MGP_FVBNJ_G0022529	protein coding gene	Chr16:27746561-27765098 (-)
LP/J	MGP_LPJ_G0022621	protein coding gene	Chr16:29066379-29084905 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022548	protein coding gene	Chr16:30620793-30639364 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023147	protein coding gene	Chr16:28898251-28916835 (-)
PWK/PhJ	MGP_PWKPhJ_G0021718	protein coding gene	Chr16:28083701-28101163 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021549	protein coding gene	Chr16:28687361-28705831 (-)
WSB/EiJ	MGP_WSBEiJ_G0022023	protein coding gene	Chr16:28851817-28871481 (-)

Human Ortholog

APOD, apolipoprotein D

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOD, apolipoprotein D
Links

HGNC:612

NCBI Gene ID: 347

neXtProt AC: NX_P05090

UniProt: P05090
Chr Location

3q29; chr3:195568705-195584033 (-) GRCh38

MGI Vertebrate Homology

Apod stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: APOD
Protein SuperFamily

Lipocalin_ApoD
Gene Tree

Apod

Diseases

2 with human APOD associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

3
Gene trapped

16
Targeted

4
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele display increased sensitivity to reactive oxygen species, impaired motor and spatial learning, and decreased vertical and horizontal activity.

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All GO Annotations

48
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1056
Tissues

97
cDNA Data

19
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA APOD

ZFIN apoda.2

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All Sequences

49
RefSeq

6
UniProt

1
CCDS

CCDS28105.1

Ensembl

ENSMUSG00000022548 (Evidence)
NCBI Gene

11815

			Length	Strain/Species	Flank
genomic	11815	NCBI Gene Model \| MGI Sequence Detail	18617	C57BL/6J	± kb
transcript	NM_007470	RefSeq \| MGI Sequence Detail	2074	ZRU/MplStud
polypeptide	P51910	UniProt \| EBI \| MGI Sequence Detail	189	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000022228 outer membrane lipoprotein Blc

(term hierarchy)
InterPro Domains

IPR002969 Apolipoprotein D

IPR026222 Apolipoprotein D, vertebrates

IPR012674 Calycin

IPR022271 Lipocalin, ApoD type

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

IPR022272 Lipocalin family conserved site
GlyGen

P51910 2 sites, 3 N-linked glycans (2 sites)

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All nucleic 33

Genomic 3

cDNA 21

Primer pair 9

Microarray probesets 3

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MGD-MRK-1375

Summaries

All 77

Developmental Gene Expression 20

Gene Ontology 7

Phenotypes 16
Earliest

J:2968 Warden CH, et al., Localization of the gene for apolipoprotein D on mouse chromosome 16. Genomics. 1992 Apr;12(4):851-2
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Apod:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140754	Chr16:31133404-31133423 (-)	212 bp
Tssr140753	Chr16:31133355-31133366 (-)	265 bp
Tssr140752	Chr16:31130146-31130159 (-)	3,473 bp
Tssr140751	Chr16:31129965-31129983 (-)	3,652 bp
Tssr140750	Chr16:31129911-31129927 (-)	3,707 bp
Tssr140749	Chr16:31129889-31129899 (-)	3,732 bp
Tssr140748	Chr16:31129870-31129882 (-)	3,750 bp
Tssr140747	Chr16:31122327-31122358 (-)	11,283 bp
Tssr140746	Chr16:31122282-31122309 (-)	11,330 bp
Tssr140745	Chr16:31120068-31120080 (-)	13,552 bp
Tssr4841	Chr16:31119326-31119329 (-)	14,298 bp
Tssr140744	Chr16:31119297-31119320 (-)	14,317 bp
Tssr140743	Chr16:31119259-31119277 (-)	14,358 bp
Tssr4840	Chr16:31116370-31116402 (-)	17,240 bp
Tssr140742	Chr16:31116321-31116343 (-)	17,294 bp
Tssr140741	Chr16:31116271-31116283 (-)	17,349 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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