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Atp2a2 Gene Detail
Summary
  • Symbol
    Atp2a2
  • Name
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • Synonyms
    9530097L16Rik, D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, Serca2a, SERCA2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:88110
    NCBI Gene: 11938
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122591576-122640288 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.38 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    987 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88110
 protein coding gene Chr5:122591576-122640288 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030053
 protein coding gene Chr5:126085200-126137282 (-)
A/J MGP_AJ_G0030018
 protein coding gene Chr5:120862592-120911860 (-)
AKR/J MGP_AKRJ_G0029954
 protein coding gene Chr5:124757277-124805473 (-)
BALB/cJ MGP_BALBcJ_G0030029
 protein coding gene Chr5:122209916-122259539 (-)
C3H/HeJ MGP_C3HHeJ_G0029746
 protein coding gene Chr5:125376811-125435498 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030482
 protein coding gene Chr5:130936258-130986404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027708
 protein coding gene Chr5:115471781-115520349 (-)
CAST/EiJ MGP_CASTEiJ_G0029155
 protein coding gene Chr5:124467979-124517084 (-)
CBA/J MGP_CBAJ_G0029716
 protein coding gene Chr5:136067326-136119045 (-)
DBA/2J MGP_DBA2J_G0029866
 protein coding gene Chr5:120919461-120968563 (-)
FVB/NJ MGP_FVBNJ_G0029822
 protein coding gene Chr5:119913282-119962639 (-)
LP/J MGP_LPJ_G0029955
 protein coding gene Chr5:126631687-126679897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029853
 protein coding gene Chr5:139808935-139859215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030523
 protein coding gene Chr5:124357379-124406857 (-)
PWK/PhJ MGP_PWKPhJ_G0028869
 protein coding gene Chr5:119698803-119749010 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028706
 protein coding gene Chr5:122052805-122102453 (-)
WSB/EiJ MGP_WSBEiJ_G0029230
 protein coding gene Chr5:125014999-125064734 (-)



Homology
more
  • Human Ortholog
    ATP2A2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP2A2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  • Synonyms
    ATP2B, DAR, DD, SERCA2
  • Links
    NCBI Gene ID: 488
    neXtProt AC: NX_P16615
    UniProt: P16615

  • Chr Location
    12q24.11; chr12:110280616-110351093 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Atp2a2 mouse models; 4 with human ATP2A2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 5 alleles in 8 genetic backgrounds
    18 phenotypes from multigenic genotypes
    3 images
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted homozygous mutants are embryonic lethal while heterozygotes show reduced blood pressure and mildly impaired cardiac contractility and relaxation. Aged heterozygotes for one targeted mutation develop squamous cell tumors of the forestomach, esophagus, oral mucosa, tongue, and skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    945
  • Tissues
    113
  • cDNA Data
    21
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11938 NCBI Gene Model | MGI Sequence Detail 48713 C57BL/6J ±  kb
    transcript NR_027838 RefSeq | MGI Sequence Detail 5763 ZRU/MplStud  
    polypeptide O55143 UniProt | EBI | MGI Sequence Detail 1044 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004443 sarcoplasmic/endoplasmic reticulum calcium ATPase 2
      (term hierarchy)
    • EC
      7.2.2.10
    • InterPro Domains
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR001757 P-type ATPase
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR044492 P-type ATPase, haloacid dehalogenase domain
      IPR018303 P-type ATPase, phosphorylation site
      IPR005782 P-type ATPase, subfamily IIA, SERCA-type
      IPR023298 P-type ATPase, transmembrane domain superfamily
    • GlyGen
      O55143 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 2
      cDNA 25
      Primer pair 15
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1463, MGD-MRK-35783, MGI:107317, MGI:2441754
    References
    more
    • Summaries
      All 261
      Developmental Gene Expression 76
      Diseases 1
      Gene Ontology 37
      Phenotypes 72
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:349860 Hashimoto K, et al., Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory