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Slc7a1 Gene Detail
Summary
  • Symbol
    Slc7a1
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
  • Synonyms
    4831426K01Rik, Atrc-1, Atrc1, Cat1, mCAT-1, Rec-1, Rev-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88117
    NCBI Gene: 11987
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:148264220-148336714 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 88.48 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2692 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88117
 protein coding gene Chr5:148264220-148336714 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030395
 protein coding gene Chr5:154055924-154131915 (-)
A/J MGP_AJ_G0030368
 protein coding gene Chr5:147489225-147560967 (-)
AKR/J MGP_AKRJ_G0030295
 protein coding gene Chr5:152053893-152129951 (-)
BALB/cJ MGP_BALBcJ_G0030377
 protein coding gene Chr5:148741363-148814656 (-)
C3H/HeJ MGP_C3HHeJ_G0030091
 protein coding gene Chr5:153017883-153093317 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030832
 protein coding gene Chr5:159726705-159811195 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028045
 protein coding gene Chr5:141900653-141973554 (-)
CAST/EiJ MGP_CASTEiJ_G0029493
 protein coding gene Chr5:152598300-152674235 (-)
CBA/J MGP_CBAJ_G0030069
 protein coding gene Chr5:166388503-166481935 (-)
DBA/2J MGP_DBA2J_G0030213
 protein coding gene Chr5:147176615-147251519 (-)
FVB/NJ MGP_FVBNJ_G0030167
 protein coding gene Chr5:146396085-146469936 (-)
LP/J MGP_LPJ_G0030300
 protein coding gene Chr5:154745501-154828707 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030203
 protein coding gene Chr5:168598409-168688515 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030862
 protein coding gene Chr5:151973632-152050753 (-)
PWK/PhJ MGP_PWKPhJ_G0029207
 protein coding gene Chr5:146302544-146381343 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029043
 protein coding gene Chr5:149291522-149362828 (-)
WSB/EiJ MGP_WSBEiJ_G0029570
 protein coding gene Chr5:152783497-152860658 (-)



Homology
more
  • Human Ortholog
    SLC7A1, solute carrier family 7 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A1, solute carrier family 7 member 1
  • Synonyms
    ATRC1, CAT-1, ERR, HCAT1, REC1L
  • Links
    NCBI Gene ID: 6541
    neXtProt AC: NX_P30825
    UniProt: P30825

  • Chr Location
    13q12.3; chr13:29509414-29595688 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants die on the first day of birth and are very anemic. Peripheral blood contains 50% fewer red blood cells, reduced hemoglobin levels, and a defect in erythroid maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    60
  • cDNA Data
    85
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11987 NCBI Gene Model | MGI Sequence Detail 72495 C57BL/6J ±  kb
    transcript NM_001429137 RefSeq | MGI Sequence Detail 7451 C57BL/6  
    polypeptide Q09143 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 85
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13821, MGD-MRK-13847, MGD-MRK-1478, MGD-MRK-1479, MGI:2140881
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:5854 Gazdar AF, et al., Identification of mouse chromosomes required for murine leukemia virus replication. Cell. 1977 Aug;11(4):949-56
    • Latest
      J:326352 Yamaguchi H, et al., Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice. Dev Dyn. 2022 Jul;251(7):1209-1222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory