Av1 QTL Detail

Summary

• Symbol
  Av1
• Name
  Abelson virus susceptibility 1
• Synonyms
  Av-1

• Feature Type
  QTL
• IDs
  MGI:88119
  NCBI Gene: 107483

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

This locus, with Av2, controls susceptibility to induction of non-thymic lymphomas by Abelson leukemia virus (A-MuLV), which is a complex of defective virus and non-defective Moloney leukemia virus. Resistance to the defective virus is responsible for the resistance phenotype.

Sequences &
Gene Models

• NCBI Gene
  107483

Other
Accession IDs

MGD-MRK-1481, MGD-MRK-1483

References

• Summaries
  All 4
• Earliest
  J:6046 Risser R, et al., Abelson virus-induced lymphomagenesis in mice. J Exp Med. 1978 Sep 1;148(3):714-26
• Latest
  J:6225 Risser R, Abelson antigen is expressed on hematopoietic spleen colony-forming cells from mice carrying the Av-2S virus sensitivity gene. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5350-4