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Tff1 Gene Detail
Summary
  • Symbol
    Tff1
  • Name
    trefoil factor 1
  • Synonyms
    Bcei, PS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88135
    NCBI Gene: 21784
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:31380369-31384034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88135
 protein coding gene Chr17:31380369-31384251 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023483
 protein coding gene Chr17:30901100-30904762 (-)
A/J MGP_AJ_G0023441
 protein coding gene Chr17:29891963-29895620 (-)
AKR/J MGP_AKRJ_G0023406
 protein coding gene Chr17:30136245-30139902 (-)
BALB/cJ MGP_BALBcJ_G0023446
 protein coding gene Chr17:29999338-30003000 (-)
C3H/HeJ MGP_C3HHeJ_G0023207
 protein coding gene Chr17:30522024-30525681 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023888
 protein coding gene Chr17:31967973-31971630 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021362
 protein coding gene Chr17:27032518-27036175 (-)
CAST/EiJ MGP_CASTEiJ_G0022708
 protein coding gene Chr17:30550057-30553714 (-)
CBA/J MGP_CBAJ_G0023182
 protein coding gene Chr17:33393794-33397451 (-)
DBA/2J MGP_DBA2J_G0023312
 protein coding gene Chr17:29309796-29313458 (-)
FVB/NJ MGP_FVBNJ_G0023282
 protein coding gene Chr17:29092768-29096421 (-)
LP/J MGP_LPJ_G0023390
 protein coding gene Chr17:31120423-31124085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023300
 protein coding gene Chr17:32454838-32458490 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023930
 protein coding gene Chr17:30511787-30515444 (-)
PWK/PhJ MGP_PWKPhJ_G0022458
 protein coding gene Chr17:28125366-28129018 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022276
 protein coding gene Chr17:28496897-28500550 (-)
WSB/EiJ MGP_WSBEiJ_G0022770
 protein coding gene Chr17:30469675-30473332 (-)



Homology
more
  • Human Ortholog
    TFF1, trefoil factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFF1, trefoil factor 1
  • Synonyms
    BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
  • Links
    NCBI Gene ID: 7031
    neXtProt AC: NX_P04155
    UniProt: P04155

  • Chr Location
    21q22.3; chr21:42362282-42366535 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tff1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    130
  • cDNA Data
    15
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21784 NCBI Gene Model | MGI Sequence Detail 3666 C57BL/6J ±  kb
    transcript NM_009362 RefSeq | MGI Sequence Detail 478 ZRU/MplStud  
    polypeptide Q08423 UniProt | EBI | MGI Sequence Detail 87 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1519
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 12
      Diseases 4
      Gene Ontology 8
      Phenotypes 64
    • Earliest
      J:12836 Lefebvre O, et al., The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol. 1993 Jul;122(1):191-8
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory