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Bcl2 Gene Detail
Summary
  • Symbol
    Bcl2
  • Name
    B cell leukemia/lymphoma 2
  • Synonyms
    Bcl-2, C430015F12Rik, D830018M01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88138
    NCBI Gene: 12043
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:106465908-106642004 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 49.76 cM
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4413 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    8
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88138
 protein coding gene Chr1:106465906-106642020 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016371
 protein coding gene Chr1:108706936-108894106 (-)
A/J MGP_AJ_G0016355
 protein coding gene Chr1:104900660-105077758 (-)
AKR/J MGP_AKRJ_G0016315
 protein coding gene Chr1:107761637-107949955 (-)
BALB/cJ MGP_BALBcJ_G0016311
 protein coding gene Chr1:104993874-105175271 (-)
C3H/HeJ MGP_C3HHeJ_G0016138
 protein coding gene Chr1:108219596-108401083 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016770
 protein coding gene Chr1:112847969-113035252 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014488
 protein coding gene Chr1:99212578-99384146 (-)
CAST/EiJ MGP_CASTEiJ_G0015720
 protein coding gene Chr1:107139816-107322418 (-)
CBA/J MGP_CBAJ_G0016111
 protein coding gene Chr1:116710669-116904122 (-)
DBA/2J MGP_DBA2J_G0016216
 protein coding gene Chr1:103970359-104147077 (-)
FVB/NJ MGP_FVBNJ_G0016217
 protein coding gene Chr1:102904789-103079533 (-)
LP/J MGP_LPJ_G0016290
 protein coding gene Chr1:109958128-110135746 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016243
 protein coding gene Chr1:121125772-121313444 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016809
 protein coding gene Chr1:107857819-108038591 (-)
PWK/PhJ MGP_PWKPhJ_G0015508
 protein coding gene Chr1:102992993-103170366 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015293
 protein coding gene Chr1:106519910-106696303 (-)
WSB/EiJ MGP_WSBEiJ_G0015783
 protein coding gene Chr1:107687031-107867655 (-)



Homology
more
  • Human Ortholog
    BCL2, BCL2 apoptosis regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL2, BCL2 apoptosis regulator
  • Synonyms
    Bcl-2, PPP1R50
  • Links
    NCBI Gene ID: 596
    neXtProt AC: NX_P10415
    UniProt: P10415

  • Chr Location
    18q21.33; chr18:63123346-63320128 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bcl2 mouse models; 11 with human BCL2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    135 phenotypes from 8 alleles in 8 genetic backgrounds
    47 phenotypes from multigenic genotypes
    6 images
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show pleiotropic abnormalities including small size, increased postnatal mortality, polycystic kidneys, apoptotic involution of thymus and spleen, graying in the second hair follicle cycle, and reduced numbers of motor, sympathetic and sensory neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    320
  • GO References
    118
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1229
  • Tissues
    222
  • cDNA Data
    22
  • Literature Summary
    128
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057329 Ensembl Gene Model | MGI Sequence Detail 176097 C57BL/6J ±  kb
    transcript ENSMUST00000112751 Ensembl | MGI Sequence Detail 7191 Not Applicable  
    polypeptide ENSMUSP00000108371 Ensembl | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 15
      cDNA 25
      Primer pair 22
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1524, MGD-MRK-1526, MGI:2138629, MGI:2442315, MGI:2444619, MGI:2444682
    References
    more
    • Summaries
      All 620
      Developmental Gene Expression 128
      Diseases 1
      Gene Ontology 118
      Phenotypes 114
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354455 Chen X, et al., SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development. Int J Biol Macromol. 2024 Aug;274(Pt 2):133294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory