Bcr MGI Mouse Gene Detail - MGI:88141 - BCR activator of RhoGEF and GTPase

Symbol

Bcr
Name

BCR activator of RhoGEF and GTPase
Synonyms

5133400C09Rik, breakpoint cluster region, mKIAA3017

Feature Type

protein coding gene
IDs

MGI:88141
NCBI Gene: 110279
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:74896424-75020753 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.49 cM
Mapping Data

16 experiments

SNPs within 2kb

3460 from dbSNP Build 142
Strain Annotations

18
RFLP

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88141	protein coding gene	Chr10:74896384-75020753 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017351	protein coding gene	Chr10:75197273-75328946 (+)
A/J	MGP_AJ_G0017328	protein coding gene	Chr10:72621837-72746210 (+)
AKR/J	MGP_AKRJ_G0017289	protein coding gene	Chr10:74556377-74682438 (+)
BALB/cJ	MGP_BALBcJ_G0017288	protein coding gene	Chr10:72817412-72942835 (+)
C3H/HeJ	MGP_C3HHeJ_G0017112	protein coding gene	Chr10:74609295-74737544 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017746	protein coding gene	Chr10:77868743-77995632 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015436	protein coding gene	Chr10:69089172-69213154 (+)
CAST/EiJ	MGP_CASTEiJ_G0016682	protein coding gene	Chr10:74920240-75051750 (+)
CBA/J	MGP_CBAJ_G0017084	protein coding gene	Chr10:80917508-81051216 (+)
DBA/2J	MGP_DBA2J_G0017189	protein coding gene	Chr10:71926597-72051176 (+)
FVB/NJ	MGP_FVBNJ_G0017182	protein coding gene	Chr10:71073405-71199823 (+)
LP/J	MGP_LPJ_G0017262	protein coding gene	Chr10:75688421-75812644 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017210	protein coding gene	Chr10:83040355-83166890 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017785	protein coding gene	Chr10:74595454-74724677 (+)
PWK/PhJ	MGP_PWKPhJ_G0016466	protein coding gene	Chr10:71729642-71863686 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016249	protein coding gene	Chr10:73844556-73976542 (+)
WSB/EiJ	MGP_WSBEiJ_G0016746	protein coding gene	Chr10:74564500-74689942 (+)

Human Ortholog

BCR, BCR activator of RhoGEF and GTPase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCR, BCR activator of RhoGEF and GTPase
Synonyms

ALL, BCR1, CML, D22S11, D22S662, PHL
Links

HGNC:1014

NCBI Gene ID: 613

neXtProt AC: NX_P11274

UniProt: P11274
Chr Location

22q11.23; chr22:23179704-23318037 (+) GRCh38

MGI Vertebrate Homology

Bcr stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BCR
Gene Tree

Bcr

Diseases

3 with human BCR associations

				Human Disease	Mouse Models
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				chronic myeloid leukemia IDs chronic myeloid leukemia DOID:8552 DOID:8551 DOID:8606 EFO:0000339 ICD9CM:205.1 KEGG:05220 OMIM:608232 ORDO:521 UMLS_CUI:C0023473
				leukemia IDs leukemia DOID:1240 DOID:9145 ICD10CM:C95.90 ICD9CM:208 ICD9CM:208.9 MESH:D007938 NCI:C3161 UMLS_CUI:C0023418

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 2 alleles in 5 genetic backgrounds
27 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

8
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Bcr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia.

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All GO Annotations

87
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

34
cDNA Data

125
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BCR

Xenbase bcr

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All Sequences

53
RefSeq

7
UniProt

6
CCDS

CCDS35935.1

Ensembl

ENSMUSG00000009681 (Evidence)
NCBI Gene

110279

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009681	Ensembl Gene Model \| MGI Sequence Detail	124330	C57BL/6J	± kb
transcript	ENSMUST00000164107	Ensembl \| MGI Sequence Detail	6839	Not Applicable
polypeptide	ENSMUSP00000126377	Ensembl \| MGI Sequence Detail	1270	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004712 breakpoint cluster region protein

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR037769 Abr/Bcr

IPR015123 Bcr-Abl oncoprotein oligomerisation

IPR036481 Bcr-Abl oncoprotein oligomerisation domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein
GlyGen

Q6PAJ1 1 site, 1 O-linked glycan (1 site)

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All nucleic 130

Genomic 1

cDNA 126

Primer pair 1

Other 2

Microarray probesets 6

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MGD-MRK-1530, MGI:1918508, MGI:2143646, MGI:2143694

Summaries

All 125

Developmental Gene Expression 5

Gene Ontology 21

Phenotypes 34
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:342802 Wang N, et al., Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 Oct 19;110(20):3318-3338.e9

TSS for Bcr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94071	Chr10:74896383-74896460 (+)	-2 bp
Tssr94072	Chr10:74896655-74896680 (+)	244 bp
Tssr94073	Chr10:74896717-74896733 (+)	301 bp
Tssr94074	Chr10:74934286-74934287 (+)	37,863 bp
Tssr94075	Chr10:74966399-74966463 (+)	70,007 bp
Tssr94076	Chr10:74966813-74966833 (+)	70,399 bp
Tssr94077	Chr10:75009622-75009630 (+)	113,202 bp
Tssr94078	Chr10:75009676-75009684 (+)	113,256 bp
Tssr94079	Chr10:75009798-75009812 (+)	113,381 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24