Blvra MGI Mouse Gene Detail - MGI:88170

Symbol

Blvra
Name

biliverdin reductase A
Synonyms

0610006A11Rik, 2500001N03Rik, Blvr

Feature Type

protein coding gene
IDs

MGI:88170
NCBI Gene: 109778
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:126912585-126939004 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM, cytoband F3
Mapping Data

7 experiments

SNPs within 2kb

775 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88170	protein coding gene	Chr2:126912549-126939004 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026448	protein coding gene	Chr2:130322802-130349810 (+)
A/J	MGP_AJ_G0026412	protein coding gene	Chr2:125049186-125076451 (+)
AKR/J	MGP_AKRJ_G0026387	protein coding gene	Chr2:128614519-128641196 (+)
BALB/cJ	MGP_BALBcJ_G0026424	protein coding gene	Chr2:125323922-125350170 (+)
C3H/HeJ	MGP_C3HHeJ_G0026167	protein coding gene	Chr2:129129197-129156653 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026869	protein coding gene	Chr2:134434018-134459704 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024246	protein coding gene	Chr2:119752025-119775993 (+)
CAST/EiJ	MGP_CASTEiJ_G0025628	protein coding gene	Chr2:129339255-129369684 (+)
CBA/J	MGP_CBAJ_G0026147	protein coding gene	Chr2:139395557-139425743 (+)
DBA/2J	MGP_DBA2J_G0026281	protein coding gene	Chr2:124447248-124473119 (+)
FVB/NJ	MGP_FVBNJ_G0026245	protein coding gene	Chr2:123110700-123136380 (+)
LP/J	MGP_LPJ_G0026386	protein coding gene	Chr2:130575201-130601377 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026265	protein coding gene	Chr2:143446501-143475315 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026924	protein coding gene	Chr2:128645101-128673541 (+)
PWK/PhJ	MGP_PWKPhJ_G0025364	protein coding gene	Chr2:123993774-124021877 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025166	protein coding gene	Chr2:127710076-127731784 (+)
WSB/EiJ	MGP_WSBEiJ_G0025702	protein coding gene	Chr2:129535739-129563470 (+)

Human Ortholog

BLVRA, biliverdin reductase A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BLVRA, biliverdin reductase A
Synonyms

BLVR, BVR, BVRA, BVRalpha
Links

HGNC:1062

NCBI Gene ID: 644

neXtProt AC: NX_P53004

UniProt: P53004
Chr Location

7p13; chr7:43758122-43807342 (+) GRCh38

MGI Vertebrate Homology

Blvra stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BLVRA
Protein SuperFamily

Biliverdin_reductase_A
Gene Tree

Blvra

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

28
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Blvra
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit high mean erythrocyte cell number, increased mean corpuscular hemoglobin concentration, decreased mean corpuscular volume, decreased mean corpuscular hemoglobin, green gall bladder, yellow bile, bile composed of biliverdin rather than bilirubin, and increased endogenous oxidative stress.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

42
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase blvra

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All Sequences

63
RefSeq

16
UniProt

5
CCDS

CCDS16692.1

Ensembl

ENSMUSG00000001999 (Evidence)
NCBI Gene

109778

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001999	Ensembl Gene Model \| MGI Sequence Detail	26420	C57BL/6J	± kb
transcript	ENSMUST00000002064	Ensembl \| MGI Sequence Detail	1160	Not Applicable
polypeptide	ENSMUSP00000002064	Ensembl \| MGI Sequence Detail	295	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004765 biliverdin reductase A

(term hierarchy)
EC

1.3.1.24
InterPro Domains

IPR017094 Biliverdin reductase A

IPR015249 Biliverdin reductase, catalytic

IPR000683 Gfo/Idh/MocA-like oxidoreductase, N-terminal

IPR051450 Gfo/Idh/MocA Oxidoreductases

IPR036291 NAD(P)-binding domain superfamily
GlyGen

Q9CY64 1 site, 1 O-linked glycan (1 site)

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All nucleic 43

cDNA 43

Microarray probesets 3

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MGD-MRK-1581, MGI:1915580, MGI:1917355

Summaries

All 55

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Blvra:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19976	Chr2:126912566-126912629 (+)	13 bp
Tssr19977	Chr2:126920840-126920845 (+)	8,258 bp
Tssr19978	Chr2:126922112-126922131 (+)	9,537 bp
Tssr19979	Chr2:126922157-126922168 (+)	9,578 bp
Tssr19980	Chr2:126922172-126922182 (+)	9,592 bp
Tssr19981	Chr2:126922389-126922417 (+)	9,818 bp
Tssr19982	Chr2:126922431-126922450 (+)	9,856 bp
Tssr19983	Chr2:126922489-126922500 (+)	9,910 bp
Tssr19984	Chr2:126923476-126923480 (+)	10,893 bp
Tssr19985	Chr2:126925302-126925318 (+)	12,725 bp
Tssr19986	Chr2:126928374-126928410 (+)	15,807 bp
Tssr19987	Chr2:126929409-126929417 (+)	16,828 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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