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C8b Gene Detail
Summary
  • Symbol
    C8b
  • Name
    complement component 8, beta polypeptide
  • Synonyms
    4930439B20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88236
    NCBI Gene: 110382
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:104623514-104661745 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 48.61 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1001 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88236
 protein coding gene Chr4:104623514-104661745 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028510
 protein coding gene Chr4:105286801-105326668 (+)
A/J MGP_AJ_G0028473
 protein coding gene Chr4:101571145-101609934 (+)
AKR/J MGP_AKRJ_G0028420
 protein coding gene Chr4:104032737-104076152 (+)
BALB/cJ MGP_BALBcJ_G0028492
 protein coding gene Chr4:101766708-101805108 (+)
C3H/HeJ MGP_C3HHeJ_G0028206
 protein coding gene Chr4:104804139-104842905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028932
 protein coding gene Chr4:109168820-109212858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026223
 protein coding gene Chr4:96878616-96918439 (+)
CAST/EiJ MGP_CASTEiJ_G0027642
 protein coding gene Chr4:102571391-102614367 (+)
CBA/J MGP_CBAJ_G0028175
 protein coding gene Chr4:112663117-112703265 (+)
DBA/2J MGP_DBA2J_G0028323
 protein coding gene Chr4:101219623-101258006 (+)
FVB/NJ MGP_FVBNJ_G0028291
 protein coding gene Chr4:100061955-100100970 (+)
LP/J MGP_LPJ_G0028424
 protein coding gene Chr4:105487603-105528036 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028317
 protein coding gene Chr4:118034955-118076116 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028967
 protein coding gene Chr4:104274311-104312283 (+)
PWK/PhJ MGP_PWKPhJ_G0027368
 protein coding gene Chr4:99427214-99469257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027192
 protein coding gene Chr4:101655294-101698010 (+)
WSB/EiJ MGP_WSBEiJ_G0027722
 protein coding gene Chr4:104439394-104480805 (+)



Homology
more
  • Human Ortholog
    C8B, complement C8 beta chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C8B, complement C8 beta chain
  • Synonyms
    C82
  • Links
    NCBI Gene ID: 732
    neXtProt AC: NX_P07358
    UniProt: P07358

  • Chr Location
    1p32.2; chr1:56929207-56974383 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C8B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In a controlled microbial environment ("clean") laboratory, mice homozygous for an inactivating mutation of this gene are viable and fertile and exhibit no apparent abonormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    8
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110382 NCBI Gene Model | MGI Sequence Detail 38232 C57BL/6J ±  kb
    transcript NM_133882 RefSeq | MGI Sequence Detail 2239 ZRU/MplStud  
    polypeptide Q8BH35 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000004909 complement component C8 beta chain
      (term hierarchy)
    • InterPro Domains
      IPR048831 Complement components C8A/B/C6, EGF-like domain
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR001862 Membrane attack complex component/perforin/complement C9
      IPR020863 Membrane attack complex component/perforin domain, conserved site
      IPR020864 Membrane attack complex component/perforin (MACPF) domain
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    • GlyGen
      Q8BH35 6 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1714, MGI:1921221, MGI:2140338
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:3321 Bahary N, et al., Molecular genetic linkage maps of mouse chromosomes 4 and 6. Genomics. 1991 Sep;11(1):33-47
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory