Caf Gene Detail

Summary

• Symbol
  Caf
• Name
  caffeine susceptibility

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:88243
  NCBI Gene: 104272
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

This locus controls sensitivity to acute toxic effects of intraperitoneal caffeine injection. CBA/J mice have clonic seizures and rapidly die. SWR mice survive and have no seizures. The response difference does not appear due to differences in caffeine metabolism.

Sequences &
Gene Models

• NCBI Gene
  104272

Other
Accession IDs

MGD-MRK-1724

References

• Summaries
  All 3
• Earliest
  J:8081 Seale TW, et al., A single gene difference determines relative susceptibility to caffeine-induced lethality in SWR and CBA inbred mice. Pharmacol Biochem Behav. 1985 Aug;23(2):275-8
• Latest
  J:8861 Seale TW, et al., Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM. Pharmacol Biochem Behav. 1987 Jul;27(3):451-6