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Calb1 Gene Detail
Summary
  • Symbol
    Calb1
  • Name
    calbindin 1
  • Synonyms
    Brain-2, Calb, Calb-1, calbindin, calbindin-D (28k), CalbindinD28K, CB
  • Feature Type
    protein coding gene
  • IDs
    MGI:88248
    NCBI Gene: 12307
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:15881264-15906709 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 6.66 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    615 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88248
 protein coding gene Chr4:15881264-15908064 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028072
 protein coding gene Chr4:12773093-12802387 (+)
A/J MGP_AJ_G0028030
 protein coding gene Chr4:12430418-12457813 (+)
AKR/J MGP_AKRJ_G0027995
 protein coding gene Chr4:12661291-12688851 (+)
BALB/cJ MGP_BALBcJ_G0028041
 protein coding gene Chr4:12371510-12398824 (+)
C3H/HeJ MGP_C3HHeJ_G0027771
 protein coding gene Chr4:12771296-12799407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028484
 protein coding gene Chr4:13293213-13321570 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025826
 protein coding gene Chr4:11624730-11651094 (+)
CAST/EiJ MGP_CASTEiJ_G0027226
 protein coding gene Chr4:12610932-12641828 (+)
CBA/J MGP_CBAJ_G0027744
 protein coding gene Chr4:13611320-13642428 (+)
DBA/2J MGP_DBA2J_G0027887
 protein coding gene Chr4:12260813-12292763 (+)
FVB/NJ MGP_FVBNJ_G0027853
 protein coding gene Chr4:12037572-12064283 (+)
LP/J MGP_LPJ_G0027996
 protein coding gene Chr4:12812593-12839713 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027886
 protein coding gene Chr4:13960711-13988258 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028543
 protein coding gene Chr4:12635269-12665954 (+)
PWK/PhJ MGP_PWKPhJ_G0026946
 protein coding gene Chr4:12234519-12262142 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026775
 protein coding gene Chr4:12514831-12541876 (+)
WSB/EiJ MGP_WSBEiJ_G0027303
 protein coding gene Chr4:12665686-12694407 (+)



Homology
more
  • Human Ortholog
    CALB1, calbindin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALB1, calbindin 1
  • Synonyms
    CALB, D-28K
  • Links
    NCBI Gene ID: 793
    neXtProt AC: NX_P05937
    UniProt: P05937

  • Chr Location
    8q21.3; chr8:90058608-90095475 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants show severely impairment in motor coordination and Purkinje cells in the cerebellum show changes of synaptically evoked postsynaptic calcium transients.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2459
  • Tissues
    464
  • cDNA Data
    85
  • Literature Summary
    1052
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12307 NCBI Gene Model | MGI Sequence Detail 25446 C57BL/6J ±  kb
    transcript NM_009788 RefSeq | MGI Sequence Detail 2867 ZRU/MplStud  
    polypeptide P12658 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 9
      cDNA 86
      Primer pair 10
      Other 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1729, MGD-MRK-1730, MGD-MRK-1731
    References
    more
    • Summaries
      All 1242
      Developmental Gene Expression 1052
      Gene Ontology 26
      Phenotypes 99
    • Earliest
      J:9499 Nordquist DT, et al., cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons. J Neurosci. 1988 Dec;8(12):4780-9
    • Latest
      J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory