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Cald1 Gene Detail
Summary
  • Symbol
    Cald1
  • Name
    caldesmon 1
  • Synonyms
    4833423D12Rik, C920027I18Rik, MGC:30319
  • Feature Type
    protein coding gene
  • IDs
    MGI:88250
    NCBI Gene: 109624
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34575433-34752404 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4756 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88250
 protein coding gene Chr6:34575433-34752408 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030561
 protein coding gene Chr6:32688030-32877142 (+)
A/J MGP_AJ_G0030534
 protein coding gene Chr6:31287939-31468042 (+)
AKR/J MGP_AKRJ_G0030461
 protein coding gene Chr6:32347714-32538241 (+)
BALB/cJ MGP_BALBcJ_G0030544
 protein coding gene Chr6:31467998-31648264 (+)
C3H/HeJ MGP_C3HHeJ_G0030257
 protein coding gene Chr6:32298889-32486131 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030998
 protein coding gene Chr6:33511648-33699870 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028210
 protein coding gene Chr6:29380913-29558681 (+)
CAST/EiJ MGP_CASTEiJ_G0029659
 protein coding gene Chr6:32122483-32311847 (+)
CBA/J MGP_CBAJ_G0030235
 protein coding gene Chr6:34793982-34995971 (+)
DBA/2J MGP_DBA2J_G0030379
 protein coding gene Chr6:31164209-31345410 (+)
FVB/NJ MGP_FVBNJ_G0030333
 protein coding gene Chr6:30958834-31138445 (+)
LP/J MGP_LPJ_G0030466
 protein coding gene Chr6:32811960-32991752 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030369
 protein coding gene Chr6:37131682-37322699 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031028
 protein coding gene Chr6:32222356-32407180 (+)
PWK/PhJ MGP_PWKPhJ_G0029373
 protein coding gene Chr6:30776809-30959177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029209
 protein coding gene Chr6:31894851-32079021 (+)
WSB/EiJ MGP_WSBEiJ_G0029735
 protein coding gene Chr6:32146522-32337339 (+)



Homology
more
  • Human Ortholog
    CALD1, caldesmon 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALD1, caldesmon 1
  • Synonyms
    CDM, H-CAD, HCAD, h-CD, L-CAD, LCAD, NAG22
  • Links
    NCBI Gene ID: 800
    neXtProt AC: NX_Q05682
    UniProt: Q05682

  • Chr Location
    7q33; chr7:134744252-134970729 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some homozygous mutant mice develop hernia and those that do, die within 5-7 hours after birth. Mice homozygous for a different targeted allele fail to develop. Mice heterozygous for this allele exhibit increased urinary bladder weight, smooth muscle bundles and non-voiding contractions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    16
  • cDNA Data
    15
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109624 NCBI Gene Model | MGI Sequence Detail 176972 C57BL/6J ±  kb
    transcript NM_001347100 RefSeq | MGI Sequence Detail 4144 ZRU/MplStud  
    polypeptide NP_001334029 RefSeq | MGI Sequence Detail 536 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • InterPro Domains
      IPR006017 Caldesmon
      IPR006018 Caldesmon/lymphocyte specific protein
    • GlyGen
      E9QA16 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1733, MGI:1353560, MGI:1921163, MGI:2141616, MGI:2141689, MGI:2444081
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 17
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:88666 Walker G, et al., The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell. J Biol Chem. 1989 Jan 5;264(1):496-500
    • Latest
      J:331266 Abou Nader N, et al., Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate. Int J Mol Sci. 2022 Nov 5;23(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory