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Calr Gene Detail
Summary
  • Symbol
    Calr
  • Name
    calreticulin
  • Synonyms
    Calregulin, CRT
  • Feature Type
    protein coding gene
  • IDs
    MGI:88252
    NCBI Gene: 12317
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85568717-85573560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.21 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88252
 protein coding gene Chr8:85568479-85573563 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033873
 protein coding gene Chr8:85765451-85770536 (-)
A/J MGP_AJ_G0033856
 protein coding gene Chr8:82385674-82390762 (-)
AKR/J MGP_AKRJ_G0033782
 protein coding gene Chr8:84825077-84830162 (-)
BALB/cJ MGP_BALBcJ_G0033849
 protein coding gene Chr8:82512380-82517465 (-)
C3H/HeJ MGP_C3HHeJ_G0033559
 protein coding gene Chr8:85449545-85454633 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034369
 protein coding gene Chr8:89046694-89051778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031311
 protein coding gene Chr8:76177230-76182300 (-)
CAST/EiJ MGP_CASTEiJ_G0032889
 protein coding gene Chr8:84872287-84877373 (-)
CBA/J MGP_CBAJ_G0033535
 protein coding gene Chr8:92088717-92093806 (-)
DBA/2J MGP_DBA2J_G0033688
 protein coding gene Chr8:82025314-82030403 (-)
FVB/NJ MGP_FVBNJ_G0033636
 protein coding gene Chr8:80970478-80975566 (-)
LP/J MGP_LPJ_G0033780
 protein coding gene Chr8:85874524-85879609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033678
 protein coding gene Chr8:94644426-94649511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034386
 protein coding gene Chr8:84815577-84820663 (-)
PWK/PhJ MGP_PWKPhJ_G0032593
 protein coding gene Chr8:81271879-81276959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032429
 protein coding gene Chr8:83624593-83629632 (-)
WSB/EiJ MGP_WSBEiJ_G0033002
 protein coding gene Chr8:85242304-85247389 (-)



Homology
more
  • Human Ortholog
    CALR, calreticulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALR, calreticulin
  • Synonyms
    CALR1, cC1qR, CRT, HEL-S-99n, RO, SSA
  • Links
    NCBI Gene ID: 811
    neXtProt AC: NX_P27797
    UniProt: P27797

  • Chr Location
    19p13.13; chr19:12938578-12944489 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Calr mouse models; 13 with human CALR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 5 alleles in 5 genetic backgrounds
    7 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit decreased cardiac cell mass, increased apoptosis of cardiac myocytes, neural tube defects (sometimes associated with exencephaly), omphalocele, and mid- to late-gestational lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    124
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    43
  • cDNA Data
    13
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12317 NCBI Gene Model | MGI Sequence Detail 4844 C57BL/6J ±  kb
    transcript NM_007591 RefSeq | MGI Sequence Detail 1943 ZRU/MplStud  
    polypeptide P14211 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 13
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1739
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 34
      Diseases 1
      Gene Ontology 36
      Phenotypes 73
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory