About   Help   FAQ
Car8 Gene Detail
Summary
  • Symbol
    Car8
  • Name
    carbonic anhydrase 8
  • Synonyms
    Cals1, Carp, CA-RP VIII, wdl
  • Feature Type
    protein coding gene
  • IDs
    MGI:88253
    NCBI Gene: 12319
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:8143362-8239041 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 3.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3345 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88253
 protein coding gene Chr4:8141491-8239226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028038
 protein coding gene Chr4:4705771-4815835 (-)
A/J MGP_AJ_G0027996
 protein coding gene Chr4:4658376-4749965 (-)
AKR/J MGP_AKRJ_G0027962
 protein coding gene Chr4:4680474-4776155 (-)
BALB/cJ MGP_BALBcJ_G0028008
 protein coding gene Chr4:4633290-4727630 (-)
C3H/HeJ MGP_C3HHeJ_G0027738
 protein coding gene Chr4:4824250-4922210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028451
 protein coding gene Chr4:5002401-5110560 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025795
 protein coding gene Chr4:4269328-4467440 (-)
CAST/EiJ MGP_CASTEiJ_G0027192
 protein coding gene Chr4:4696819-4786932 (-)
CBA/J MGP_CBAJ_G0027713
 protein coding gene Chr4:5061027-5156994 (-)
DBA/2J MGP_DBA2J_G0027853
 protein coding gene Chr4:4612511-4701190 (-)
FVB/NJ MGP_FVBNJ_G0027820
 protein coding gene Chr4:4475834-4566157 (-)
LP/J MGP_LPJ_G0027964
 protein coding gene Chr4:4746036-4844705 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027853
 protein coding gene Chr4:5340309-5437713 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028510
 protein coding gene Chr4:4645693-4733883 (-)
PWK/PhJ MGP_PWKPhJ_G0026913
 protein coding gene Chr4:4616070-4716395 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026743
 protein coding gene Chr4:4628346-4726070 (-)
WSB/EiJ MGP_WSBEiJ_G0027271
 protein coding gene Chr4:4773015-4863829 (-)



Homology
more
  • Human Ortholog
    CA8, carbonic anhydrase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA8, carbonic anhydrase 8
  • Synonyms
    CALS, CAMRQ3, CA-RP, CARP, CA-VIII, SCAR34
  • Links
    NCBI Gene ID: 767
    neXtProt AC: NX_P35219
    UniProt: P35219

  • Chr Location
    8q12.1; chr8:60185412-60281400 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Car8 mouse models; 1 with human CA8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous deletion exhibit a wobbly side-to-side gait which is first noted at two weeks of age and persists throughout life.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1068
  • Tissues
    223
  • cDNA Data
    12
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041261 Ensembl Gene Model | MGI Sequence Detail 95680 C57BL/6J ±  kb
    transcript ENSMUST00000066674 Ensembl | MGI Sequence Detail 3853 Not Applicable  
    polypeptide ENSMUSP00000063511 Ensembl | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 12
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1740, MGD-MRK-19364, MGI:2140591, MGI:2449027
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 2
      Phenotypes 17
    • Earliest
      J:15409 Kato K, Sequence of a novel carbonic anhydrase-related polypeptide and its exclusive presence in Purkinje cells. FEBS Lett. 1990 Oct 1;271(1-2):137-40
    • Latest
      J:343468 Li Y, et al., Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms. iScience. 2023 Dec 15;26(12):108544
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory