Anxa6 MGI Mouse Gene Detail - MGI:88255

Symbol

Anxa6
Name

annexin A6
Synonyms

Annexin VI, Anx6, AnxVI, Cabm, Camb

Feature Type

protein coding gene
IDs

MGI:88255
NCBI Gene: 11749
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:54869934-54924271 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM
Mapping Data

11 experiments

SNPs within 2kb

1820 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88255	protein coding gene	Chr11:54869779-54924297 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018323	protein coding gene	Chr11:54478330-54535089 (-)
A/J	MGP_AJ_G0018292	protein coding gene	Chr11:52447428-52502543 (-)
AKR/J	MGP_AKRJ_G0018261	protein coding gene	Chr11:54164375-54220157 (-)
BALB/cJ	MGP_BALBcJ_G0018263	protein coding gene	Chr11:52788420-52843219 (-)
C3H/HeJ	MGP_C3HHeJ_G0018074	protein coding gene	Chr11:54104236-54162058 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018715	protein coding gene	Chr11:56133484-56191299 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016365	protein coding gene	Chr11:49882154-49935104 (-)
CAST/EiJ	MGP_CASTEiJ_G0017639	protein coding gene	Chr11:54145026-54201038 (-)
CBA/J	MGP_CBAJ_G0018049	protein coding gene	Chr11:58810006-58864833 (-)
DBA/2J	MGP_DBA2J_G0018158	protein coding gene	Chr11:52149693-52203651 (-)
FVB/NJ	MGP_FVBNJ_G0018150	protein coding gene	Chr11:51810255-51866249 (-)
LP/J	MGP_LPJ_G0018233	protein coding gene	Chr11:54930326-54989579 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018176	protein coding gene	Chr11:60011173-60067555 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018757	protein coding gene	Chr11:54172681-54229439 (-)
PWK/PhJ	MGP_PWKPhJ_G0017412	protein coding gene	Chr11:52700628-52759681 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017207	protein coding gene	Chr11:53968453-54024186 (-)
WSB/EiJ	MGP_WSBEiJ_G0017687	protein coding gene	Chr11:53821132-53876297 (-)

Human Ortholog

ANXA6, annexin A6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANXA6, annexin A6
Synonyms

ANX6, CBP68, CPB-II, p68, p70
Links

HGNC:544

NCBI Gene ID: 309

neXtProt AC: NX_P08133

UniProt: P08133
Chr Location

5q33.1; chr5:151100706-151157815 (-) GRCh38

MGI Vertebrate Homology

Anxa6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANXA6
Gene Tree

Anxa6

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

31
Spontaneous

1
Targeted

6
Genomic Mutations

2 involving Anxa6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele have normal immunological development but exhibit altered cardiomyocyte mechanics and intracellular calcium signaling.

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All GO Annotations

44
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

15
cDNA Data

286
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANXA6

Xenbase anxa6

ZFIN anxa6

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All Sequences

66
RefSeq

5
UniProt

8
CCDS

CCDS24705.1, CCDS48799.1

Ensembl

ENSMUSG00000018340 (Evidence)
NCBI Gene

11749

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018340	Ensembl Gene Model \| MGI Sequence Detail	54338	C57BL/6J	± kb
transcript	ENSMUST00000108883	Ensembl \| MGI Sequence Detail	2489	Not Applicable
polypeptide	ENSMUSP00000104511	Ensembl \| MGI Sequence Detail	673	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000004079 annexin A6

(term hierarchy)
InterPro Domains

IPR001464 Annexin

IPR002393 Annexin A6

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

IPR037104 Annexin superfamily
GlyGen

P14824 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 293

Genomic 1

cDNA 289

Primer pair 1

Other 2

Microarray probesets 5

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MGD-MRK-1719, MGD-MRK-1742, MGI:2144494

Summaries

All 84

Developmental Gene Expression 5

Diseases 1

Gene Ontology 13

Phenotypes 30
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Anxa6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108037	Chr11:54924224-54924287 (-)	15 bp
Tssr108036	Chr11:54912641-54912689 (-)	11,606 bp
Tssr108035	Chr11:54875990-54876004 (-)	48,274 bp
Tssr108034	Chr11:54873570-54873575 (-)	50,698 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24