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Canx Gene Detail
Summary
  • Symbol
    Canx
  • Name
    calnexin
  • Synonyms
    1110069N15Rik, CNX
  • Feature Type
    protein coding gene
  • IDs
    MGI:88261
    NCBI Gene: 12330
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50184788-50216500 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 30.46 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    582 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88261
 protein coding gene Chr11:50184784-50216500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018247
 protein coding gene Chr11:49467667-49498950 (-)
A/J MGP_AJ_G0018215
 protein coding gene Chr11:47568168-47599664 (-)
AKR/J MGP_AKRJ_G0018185
 protein coding gene Chr11:49082937-49114549 (-)
BALB/cJ MGP_BALBcJ_G0018185
 protein coding gene Chr11:47847003-47880003 (-)
C3H/HeJ MGP_C3HHeJ_G0017998
 protein coding gene Chr11:49086221-49120158 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018636
 protein coding gene Chr11:50928175-50968057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016288
 protein coding gene Chr11:45192369-45224575 (-)
CAST/EiJ MGP_CASTEiJ_G0017560
 protein coding gene Chr11:49062295-49095979 (-)
CBA/J MGP_CBAJ_G0017973
 protein coding gene Chr11:53286177-53325029 (-)
DBA/2J MGP_DBA2J_G0018080
 protein coding gene Chr11:47365941-47397773 (-)
FVB/NJ MGP_FVBNJ_G0018074
 protein coding gene Chr11:46995571-47027211 (-)
LP/J MGP_LPJ_G0018155
 protein coding gene Chr11:49809099-49842497 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018099
 protein coding gene Chr11:54814584-54849143 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018680
 protein coding gene Chr11:49188972-49223786 (-)
PWK/PhJ MGP_PWKPhJ_G0017338
 protein coding gene Chr11:47771456-47803709 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017133
 protein coding gene Chr11:48886138-48919969 (-)
WSB/EiJ MGP_WSBEiJ_G0017613
 protein coding gene Chr11:48827247-48858847 (-)



Homology
more
  • Human Ortholog
    CANX, calnexin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CANX, calnexin
  • Synonyms
    CNX, IP90, P90
  • Links
    NCBI Gene ID: 821
    neXtProt AC: NX_P27824
    UniProt: P27824

  • Chr Location
    5q35.3; chr5:179678628-179731641 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 6 alleles in 4 genetic backgrounds
    4 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit motor defects, loss of large myelinated nerve fibers, small size, and very high mortality between birth and 4 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    97
  • cDNA Data
    427
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020368 Ensembl Gene Model | MGI Sequence Detail 31713 C57BL/6J ±  kb
    transcript ENSMUST00000179865 Ensembl | MGI Sequence Detail 4281 Not Applicable  
    polypeptide ENSMUSP00000137440 Ensembl | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005005 calnexin
      (term hierarchy)
    • InterPro Domains
      IPR001580 Calreticulin/calnexin
      IPR018124 Calreticulin/calnexin, conserved site
      IPR009033 Calreticulin/calnexin, P domain superfamily
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    • GlyGen
      P35564 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 431
      cDNA 428
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1748, MGI:1099814, MGI:1913469, MGI:2144336
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 36
      Gene Ontology 41
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:358817 Pujol M, et al., Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier. Int J Mol Sci. 2024 Aug 27;25(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory