Capn2 MGI Mouse Gene Detail - MGI:88264

Symbol

Capn2
Name

calpain 2
Synonyms

Capa-2, Capa2, m-calpain

Feature Type

protein coding gene
IDs

MGI:88264
NCBI Gene: 12334
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:182294825-182345173 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.93 cM
Mapping Data

2 experiments

SNPs within 2kb

1821 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88264	protein coding gene	Chr1:182294818-182345175 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016895	protein coding gene	Chr1:189097610-189151059 (-)
A/J	MGP_AJ_G0016874	protein coding gene	Chr1:181390308-181441443 (-)
AKR/J	MGP_AKRJ_G0016839	protein coding gene	Chr1:186765703-186815144 (-)
BALB/cJ	MGP_BALBcJ_G0016832	protein coding gene	Chr1:182023582-182073899 (-)
C3H/HeJ	MGP_C3HHeJ_G0016656	protein coding gene	Chr1:187582392-187632462 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017295	protein coding gene	Chr1:195197873-195249742 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015002	protein coding gene	Chr1:172460485-172511865 (-)
CAST/EiJ	MGP_CASTEiJ_G0016238	protein coding gene	Chr1:186925861-186980702 (-)
CBA/J	MGP_CBAJ_G0016630	protein coding gene	Chr1:202442205-202496305 (-)
DBA/2J	MGP_DBA2J_G0016736	protein coding gene	Chr1:180167584-180217095 (-)
FVB/NJ	MGP_FVBNJ_G0016732	protein coding gene	Chr1:178304419-178354948 (-)
LP/J	MGP_LPJ_G0016811	protein coding gene	Chr1:190291343-190341729 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016764	protein coding gene	Chr1:209448523-209499676 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017332	protein coding gene	Chr1:186593762-186646078 (-)
PWK/PhJ	MGP_PWKPhJ_G0016026	protein coding gene	Chr1:179355333-179408492 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015802	protein coding gene	Chr1:185553932-185605041 (-)
WSB/EiJ	MGP_WSBEiJ_G0016301	protein coding gene	Chr1:186787594-186841148 (-)

Human Ortholog

CAPN2, calpain 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPN2, calpain 2
Synonyms

CANP2, CANPL2, CANPml, mCANP
Links

HGNC:1479

NCBI Gene ID: 824

neXtProt AC: NX_P17655

UniProt: P17655
Chr Location

1q41; chr1:223701593-223776018 (+) GRCh38

MGI Vertebrate Homology

Capn2 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CAPN2
Gene Tree

Capn2

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
8 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure.

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All GO Annotations

88
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

39
cDNA Data

172
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAPN2

Xenbase capn2

ZFIN capn2a, capn2b, capn2l

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All Sequences

66
RefSeq

2
UniProt

4
CCDS

CCDS35813.1

Ensembl

ENSMUSG00000026509 (Evidence)
NCBI Gene

12334

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026509	Ensembl Gene Model \| MGI Sequence Detail	50349	C57BL/6J	± kb
transcript	ENSMUST00000068505	Ensembl \| MGI Sequence Detail	3225	Not Applicable
polypeptide	ENSMUSP00000068895	Ensembl \| MGI Sequence Detail	700	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005015 calpain-2 catalytic subunit

(term hierarchy)
EC

3.4.22.53
InterPro Domains

IPR050420 Calpain

IPR036213 Calpain large subunit, domain III superfamily

IPR033883 Calpain subdomain III

IPR042736 CAPN2, penta-EF hand, calcium binding motif

IPR000169 Cysteine peptidase, cysteine active site

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR038765 Papain-like cysteine peptidase superfamily

IPR001300 Peptidase C2, calpain, catalytic domain

IPR022683 Peptidase C2, calpain, domain III

IPR022684 Peptidase C2, calpain family

IPR022682 Peptidase C2, calpain, large subunit, domain III
GlyGen

O08529 1 site, 1 O-linked glycan (1 site)

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All nucleic 177

cDNA 175

Primer pair 2

Microarray probesets 3

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MGD-MRK-1751, MGD-MRK-1755, MGI:2138213

Summaries

All 85

Developmental Gene Expression 12

Gene Ontology 19

Phenotypes 7
Earliest

J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
Latest

J:348877 Wang LH, et al., Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration. J Neurosci. 2022 Jun 22;42(25):5102-5114

TSS for Capn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15624	Chr1:182345305-182345339 (-)	-149 bp
Tssr15623	Chr1:182345181-182345192 (-)	-14 bp
Tssr15622	Chr1:182345129-182345180 (-)	18 bp
Tssr15621	Chr1:182345117-182345128 (-)	50 bp
Tssr15620	Chr1:182345012-182345090 (-)	122 bp
Tssr15619	Chr1:182344984-182344989 (-)	186 bp
Tssr15618	Chr1:182344933-182344964 (-)	224 bp
Tssr15617	Chr1:182344920-182344929 (-)	248 bp
Tssr15616	Chr1:182296179-182296185 (-)	48,991 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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