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Car2 Gene Detail
Summary
  • Symbol
    Car2
  • Name
    carbonic anhydrase 2
  • Synonyms
    CA II, CAII, Car-2, Ltw-5, Lvtw-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88269
    NCBI Gene: 12349
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14951333-14965830 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 3.23 cM
  • Mapping Data
    43 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88269
 protein coding gene Chr3:14951329-14965830 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027079
 protein coding gene Chr3:12027528-12042424 (+)
A/J MGP_AJ_G0027043
 protein coding gene Chr3:11980167-11994197 (+)
AKR/J MGP_AKRJ_G0027013
 protein coding gene Chr3:11973141-11987615 (+)
BALB/cJ MGP_BALBcJ_G0027052
 protein coding gene Chr3:11761832-11775862 (+)
C3H/HeJ MGP_C3HHeJ_G0026792
 protein coding gene Chr3:12303537-12317567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027496
 protein coding gene Chr3:12837470-12853700 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024858
 protein coding gene Chr3:10278079-10292220 (+)
CAST/EiJ MGP_CASTEiJ_G0026250
 protein coding gene Chr3:12321221-12335255 (+)
CBA/J MGP_CBAJ_G0026770
 protein coding gene Chr3:13060934-13074964 (+)
DBA/2J MGP_DBA2J_G0026905
 protein coding gene Chr3:11563621-11577653 (+)
FVB/NJ MGP_FVBNJ_G0026873
 protein coding gene Chr3:11382667-11396683 (+)
LP/J MGP_LPJ_G0027016
 protein coding gene Chr3:12635871-12652116 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026894
 protein coding gene Chr3:14811581-14829119 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027556
 protein coding gene Chr3:11789330-11803356 (+)
PWK/PhJ MGP_PWKPhJ_G0025985
 protein coding gene Chr3:11662514-11676754 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025788
 protein coding gene Chr3:11825730-11839849 (+)
WSB/EiJ MGP_WSBEiJ_G0026321
 protein coding gene Chr3:11865153-11881862 (+)



Homology
more
  • Human Ortholog
    CA2, carbonic anhydrase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA2, carbonic anhydrase 2
  • Synonyms
    CAC, CA-II, CAII, Car2, HEL-76, HEL-S-282
  • Links
    NCBI Gene ID: 760
    neXtProt AC: NX_P00918
    UniProt: P00918

  • Chr Location
    8q21.2; chr8:85463968-85481493 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Car2 mouse models; 2 with human CA2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    234
  • cDNA Data
    243
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027562 Ensembl Gene Model | MGI Sequence Detail 14498 C57BL/6J ±  kb
    transcript ENSMUST00000029078 Ensembl | MGI Sequence Detail 1788 Not Applicable  
    polypeptide ENSMUSP00000029078 Ensembl | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 256
      Genomic 5
      cDNA 244
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 40
      Diseases 2
      Gene Ontology 15
      Phenotypes 38
    • Earliest
      J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
    • Latest
      J:348368 Barone S, et al., Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC. Int J Mol Sci. 2024 Apr 27;25(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory