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Car3 Gene Detail
Summary
  • Symbol
    Car3
  • Name
    carbonic anhydrase 3
  • Synonyms
    Car-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88270
    NCBI Gene: 12350
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14928598-14937441 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 3.22 cM, cytoband A2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88270
 protein coding gene Chr3:14928572-14937583 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027078
 protein coding gene Chr3:12003411-12012414 (+)
A/J MGP_AJ_G0027042
 protein coding gene Chr3:11957745-11966813 (+)
AKR/J MGP_AKRJ_G0027012
 protein coding gene Chr3:11950766-11959767 (+)
BALB/cJ MGP_BALBcJ_G0027051
 protein coding gene Chr3:11739279-11748347 (+)
C3H/HeJ MGP_C3HHeJ_G0026791
 protein coding gene Chr3:12280960-12290028 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027495
 protein coding gene Chr3:12810801-12819811 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024857
 protein coding gene Chr3:10256591-10265519 (+)
CAST/EiJ MGP_CASTEiJ_G0026249
 protein coding gene Chr3:12297868-12306804 (+)
CBA/J MGP_CBAJ_G0026769
 protein coding gene Chr3:13038430-13047545 (+)
DBA/2J MGP_DBA2J_G0026904
 protein coding gene Chr3:11538195-11550148 (+)
FVB/NJ MGP_FVBNJ_G0026872
 protein coding gene Chr3:11359841-11368925 (+)
LP/J MGP_LPJ_G0027015
 protein coding gene Chr3:12608254-12617130 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026893
 protein coding gene Chr3:14786974-14795887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027555
 protein coding gene Chr3:11765135-11774333 (+)
PWK/PhJ MGP_PWKPhJ_G0025984
 protein coding gene Chr3:11638748-11647844 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025787
 protein coding gene Chr3:11802653-11823498 (+)
WSB/EiJ MGP_WSBEiJ_G0026320
 protein coding gene Chr3:11841105-11850132 (+)



Homology
more
  • Human Ortholog
    CA3, carbonic anhydrase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA3, carbonic anhydrase 3
  • Synonyms
    CAIII, Car3
  • Links
    NCBI Gene ID: 761
    neXtProt AC: NX_P07451
    UniProt: P07451

  • Chr Location
    8q21.2; chr8:85373436-85449040 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and exhibit a normal life span and a normal response to hyperoxic challenge. Mutant muscles display shorter half-relaxation times for both single and tetanic twitches but show normal fatigability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1019
  • Tissues
    162
  • cDNA Data
    442
  • Literature Summary
    32
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12350 NCBI Gene Model | MGI Sequence Detail 8844 C57BL/6J ±  kb
transcript NM_007606 RefSeq | MGI Sequence Detail 1537 ZRU/MplStud  
polypeptide P16015 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 453
    cDNA 443
    Primer pair 7
    Other 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-1761, MGD-MRK-1764, MGI:2140035
References
more
  • Summaries
    All 82
    Developmental Gene Expression 32
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:62609 Kelly CD, et al., Characterisation of cDNA clones for rat muscle carbonic anhydrase III. Biosci Rep. 1988 Oct;8(5):401-6
  • Latest
    J:351035 Tan Z, et al., Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration. Cell Rep. 2024 Jun 25;43(6):114342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory