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Ctnnb1 Gene Detail
Summary
  • Symbol
    Ctnnb1
  • Name
    catenin beta 1
  • Synonyms
    beta catenin, beta-catenin, Bfc, catenin (cadherin associated protein), beta 1, Catnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88276
    NCBI Gene: 12387
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:120762466-120789573 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88276
 protein coding gene Chr9:120758282-120789573 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035439
 protein coding gene Chr9:123837051-123868336 (+)
A/J MGP_AJ_G0035420
 protein coding gene Chr9:119153292-119185076 (+)
AKR/J MGP_AKRJ_G0035353
 protein coding gene Chr9:122318958-122350170 (+)
BALB/cJ MGP_BALBcJ_G0035416
 protein coding gene Chr9:119063348-119094669 (+)
C3H/HeJ MGP_C3HHeJ_G0035123
 protein coding gene Chr9:122782121-122817441 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035939
 protein coding gene Chr9:127206184-127237516 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032821
 protein coding gene Chr9:116330829-116362023 (+)
CAST/EiJ MGP_CASTEiJ_G0034428
 protein coding gene Chr9:122818801-122850026 (+)
CBA/J MGP_CBAJ_G0035091
 protein coding gene Chr9:131892128-131923875 (+)
DBA/2J MGP_DBA2J_G0035250
 protein coding gene Chr9:118611794-118643365 (+)
FVB/NJ MGP_FVBNJ_G0035197
 protein coding gene Chr9:117513206-117544859 (+)
LP/J MGP_LPJ_G0035329
 protein coding gene Chr9:124180646-124213081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035238
 protein coding gene Chr9:132872054-132904273 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035958
 protein coding gene Chr9:122729824-122761247 (+)
PWK/PhJ MGP_PWKPhJ_G0034132
 protein coding gene Chr9:119059389-119089842 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033968
 protein coding gene Chr9:122788666-122824490 (+)
WSB/EiJ MGP_WSBEiJ_G0034548
 protein coding gene Chr9:122596674-122630081 (+)



Homology
more
  • Human Ortholog
    CTNNB1, catenin beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNNB1, catenin beta 1
  • Synonyms
    armadillo, CTNNB, EVR7, MRD19, NEDSDV
  • Links
    NCBI Gene ID: 1499
    neXtProt AC: NX_P35222
    UniProt: P35222

  • Chr Location
    3p22.1; chr3:41194741-41260096 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with Ctnnb1 mouse models; 9 with human CTNNB1 associations

Human Disease Mouse Models
      
IDs
 View 6 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 6 models
IDs
 View 2 models
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    14 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    356 phenotypes from 17 alleles in 65 genetic backgrounds
    254 phenotypes from multigenic genotypes
    6 images
    1057 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc. Inducible KO in endothelial cells affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    496
  • GO References
    254
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2509
  • Tissues
    778
  • cDNA Data
    975
  • Literature Summary
    1176
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12387 NCBI Gene Model | MGI Sequence Detail 27108 C57BL/6J ±  kb
    transcript NM_001431672 RefSeq | MGI Sequence Detail 3543 C57BL/6  
    polypeptide Q02248 UniProt | EBI | MGI Sequence Detail 781 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1012
      cDNA 978
      Primer pair 29
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1775, MGI:2656732
    References
    more
    • Summaries
      All 2598
      Developmental Gene Expression 1176
      Diseases 14
      Gene Ontology 254
      Phenotypes 1057
    • Earliest
      J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory