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Serpina6 Gene Detail
Summary
  • Symbol
    Serpina6
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 6
  • Synonyms
    Cbg
  • Feature Type
    protein coding gene
  • IDs
    MGI:88278
    NCBI Gene: 12401
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103612889-103623471 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.98 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    398 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88278
 protein coding gene Chr12:103612889-103623477 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020055
 protein coding gene Chr12:105341038-105351620 (-)
A/J MGP_AJ_G0020010
 protein coding gene Chr12:101294705-101305287 (-)
AKR/J MGP_AKRJ_G0019987
 protein coding gene Chr12:104136738-104147351 (-)
BALB/cJ MGP_BALBcJ_G0019996
 protein coding gene Chr12:101642053-101652666 (-)
C3H/HeJ MGP_C3HHeJ_G0019799
 protein coding gene Chr12:104648189-104658771 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020446
 protein coding gene Chr12:108612981-108623563 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018058
 protein coding gene Chr12:98293321-98303753 (-)
CAST/EiJ MGP_CASTEiJ_G0019344
 protein coding gene Chr12:99465249-99475871 (-)
CBA/J MGP_CBAJ_G0019771
 protein coding gene Chr12:112660960-112671573 (-)
DBA/2J MGP_DBA2J_G0019882
 protein coding gene Chr12:100808119-100818732 (-)
FVB/NJ MGP_FVBNJ_G0019871
 protein coding gene Chr12:99537553-99548135 (-)
LP/J MGP_LPJ_G0019958
 protein coding gene Chr12:105196404-105206986 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019911
 protein coding gene Chr12:116103149-116113762 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020474
 protein coding gene Chr12:103665203-103675825 (-)
PWK/PhJ MGP_PWKPhJ_G0019106
 protein coding gene Chr12:95347957-95359058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018903
 protein coding gene Chr12:97884887-97896967 (-)
WSB/EiJ MGP_WSBEiJ_G0019399
 protein coding gene Chr12:104577354-104587966 (-)



Homology
more
  • Human Ortholog
    SERPINA6, serpin family A member 6
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA6, serpin family A member 6
  • Synonyms
    CBG
  • Links
    NCBI Gene ID: 866
    neXtProt AC: NX_P08185
    UniProt: P08185

  • Chr Location
    14q32.13; chr14:94304248-94323389 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Serpina6 mouse models; 1 with human SERPINA6 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    5
  • cDNA Data
    109
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060807 Ensembl Gene Model | MGI Sequence Detail 10583 C57BL/6J ±  kb
    transcript ENSMUST00000044159 Ensembl | MGI Sequence Detail 1605 Not Applicable  
    polypeptide ENSMUSP00000044033 Ensembl | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 3
      cDNA 109

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1778, MGI:2144779, MGI:2144981
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:3809 Scrocchi LA, et al., Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice. Endocrinology. 1993 Feb;132(2):903-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory