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Cbl Gene Detail
Summary
  • Symbol
    Cbl
  • Name
    Casitas B-lineage lymphoma
  • Synonyms
    4732447J05Rik, Cbl-2, c-Cbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:88279
    NCBI Gene: 12402
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44054273-44145346 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.72 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1785 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88279
 protein coding gene Chr9:44054273-44145556 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034694
 protein coding gene Chr9:42606886-42705763 (-)
A/J MGP_AJ_G0034675
 protein coding gene Chr9:41437899-41524460 (-)
AKR/J MGP_AKRJ_G0034601
 protein coding gene Chr9:42291375-42381788 (-)
BALB/cJ MGP_BALBcJ_G0034666
 protein coding gene Chr9:41181987-41270285 (-)
C3H/HeJ MGP_C3HHeJ_G0034377
 protein coding gene Chr9:42745337-42834184 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035187
 protein coding gene Chr9:43879994-43976971 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032102
 protein coding gene Chr9:41021990-41107118 (-)
CAST/EiJ MGP_CASTEiJ_G0033699
 protein coding gene Chr9:42584326-42672763 (-)
CBA/J MGP_CBAJ_G0034349
 protein coding gene Chr9:45475234-45569607 (-)
DBA/2J MGP_DBA2J_G0034508
 protein coding gene Chr9:41341903-41427846 (-)
FVB/NJ MGP_FVBNJ_G0034449
 protein coding gene Chr9:40591336-40676305 (-)
LP/J MGP_LPJ_G0034589
 protein coding gene Chr9:42909853-43003442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034493
 protein coding gene Chr9:47336239-47429808 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035208
 protein coding gene Chr9:42190511-42280329 (-)
PWK/PhJ MGP_PWKPhJ_G0033405
 protein coding gene Chr9:41208394-41298880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033239
 protein coding gene Chr9:42483992-42595958 (-)
WSB/EiJ MGP_WSBEiJ_G0033812
 protein coding gene Chr9:42221789-42314366 (-)



Homology
more
  • Human Ortholog
    CBL, Cbl proto-oncogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBL, Cbl proto-oncogene
  • Synonyms
    CBL2, C-CBL, FRA11B, NSLL, RNF55
  • Links
    NCBI Gene ID: 867
    neXtProt AC: NX_P22681
    UniProt: P22681

  • Chr Location
    11q23.3; chr11:119206298-119313926 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human CBL associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 5 alleles in 5 genetic backgrounds
    49 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    97
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    841
  • Tissues
    132
  • cDNA Data
    124
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034342 Ensembl Gene Model | MGI Sequence Detail 91074 C57BL/6J ±  kb
    transcript ENSMUST00000206720 Ensembl | MGI Sequence Detail 11372 Not Applicable  
    polypeptide ENSMUSP00000146244 Ensembl | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 4
      cDNA 124
      Primer pair 1
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1779, MGD-MRK-1780, MGD-MRK-1782, MGI:2443367
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 8
      Gene Ontology 27
      Phenotypes 86
    • Earliest
      J:12104 Dressler GR, et al., Murine genes with homology to Drosophila segmentation genes. Development. 1988;104 Suppl:181-6
    • Latest
      J:354878 Li X, et al., Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. Immunity. 2024 May 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory