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Cd2 Gene Detail
Summary
  • Symbol
    Cd2
  • Name
    CD2 antigen
  • Synonyms
    LFA-2, Ly-37, Ly37
  • Feature Type
    protein coding gene
  • IDs
    MGI:88320
    NCBI Gene: 12481
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:101183224-101195255 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 44.17 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88320
 protein coding gene Chr3:101183215-101195255 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027674
 protein coding gene Chr3:102442749-102454951 (-)
A/J MGP_AJ_G0027633
 protein coding gene Chr3:99201882-99213883 (-)
AKR/J MGP_AKRJ_G0027599
 protein coding gene Chr3:101645109-101657058 (-)
BALB/cJ MGP_BALBcJ_G0027646
 protein coding gene Chr3:98954940-98966959 (-)
C3H/HeJ MGP_C3HHeJ_G0027375
 protein coding gene Chr3:101937570-101950552 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028089
 protein coding gene Chr3:106212093-106224017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025430
 protein coding gene Chr3:95397935-95409934 (-)
CAST/EiJ MGP_CASTEiJ_G0026831
 protein coding gene Chr3:101035751-101047760 (-)
CBA/J MGP_CBAJ_G0027350
 protein coding gene Chr3:109851623-109865368 (-)
DBA/2J MGP_DBA2J_G0027493
 protein coding gene Chr3:98440961-98452910 (-)
FVB/NJ MGP_FVBNJ_G0027461
 protein coding gene Chr3:96379535-96394877 (-)
LP/J MGP_LPJ_G0027600
 protein coding gene Chr3:103795900-103810515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027491
 protein coding gene Chr3:116058759-116070797 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028144
 protein coding gene Chr3:101126437-101138428 (-)
PWK/PhJ MGP_PWKPhJ_G0026558
 protein coding gene Chr3:98197031-98209686 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026380
 protein coding gene Chr3:99211158-99223169 (-)
WSB/EiJ MGP_WSBEiJ_G0026911
 protein coding gene Chr3:101691763-101703711 (-)



Homology
more
  • Human Ortholog
    CD2, CD2 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD2, CD2 molecule
  • Synonyms
    LFA-2, SRBC, T11
  • Links
    NCBI Gene ID: 914
    neXtProt AC: NX_P06729
    UniProt: P06729

  • Chr Location
    1p13.1; chr1:116754430-116769229 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    48
  • cDNA Data
    26
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12481 NCBI Gene Model | MGI Sequence Detail 12032 C57BL/6J ±  kb
transcript NM_013486 RefSeq | MGI Sequence Detail 1144 ZRU/MplStud  
polypeptide P08920 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 3
    cDNA 28
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11978, MGD-MRK-1837
References
more
  • Summaries
    All 85
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:8607 Williams AF, et al., Similarities in sequences and cellular expression between rat CD2 and CD4 antigens. J Exp Med. 1987 Feb 1;165(2):368-80
  • Latest
    J:350666 Li R, et al., Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48. Cell Rep. 2024 Feb 21;43(3):113800
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory