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Cd22 Gene Detail
Summary
  • Symbol
    Cd22
  • Name
    CD22 antigen
  • Synonyms
    Lyb-8, Lyb8
  • Feature Type
    protein coding gene
  • IDs
    MGI:88322
    NCBI Gene: 12483
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30564829-30579767 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.26 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88322
 protein coding gene Chr7:30564827-30579767 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032049
 protein coding gene Chr7:29896605-29911316 (-)
A/J MGP_AJ_G0032026
 protein coding gene Chr7:29074278-29089705 (-)
AKR/J MGP_AKRJ_G0031959
 protein coding gene Chr7:29818232-29837231 (-)
BALB/cJ MGP_BALBcJ_G0032033
 protein coding gene Chr7:29263576-29279108 (-)
C3H/HeJ MGP_C3HHeJ_G0031752
 protein coding gene Chr7:30280286-30297556 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032499
 protein coding gene Chr7:30877839-30893724 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029549
 protein coding gene Chr7:30085074-30099953 (-)
CAST/EiJ MGP_CASTEiJ_G0031086
 protein coding gene Chr7:23548889-23565306 (-)
CBA/J MGP_CBAJ_G0031718
 protein coding gene Chr7:32350278-32365014 (-)
DBA/2J MGP_DBA2J_G0031870
 protein coding gene Chr7:28818545-28834840 (-)
FVB/NJ MGP_FVBNJ_G0031827
 protein coding gene Chr7:28932499-28947487 (-)
LP/J MGP_LPJ_G0031951
 protein coding gene Chr7:30215727-30241119 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031863
 protein coding gene Chr7:31581857-31598061 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032527
 protein coding gene Chr7:29327007-29349314 (-)
PWK/PhJ MGP_PWKPhJ_G0030810
 protein coding gene Chr7:23839455-23855539 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030645
 protein coding gene Chr7:20334588-20350091 (-)
WSB/EiJ MGP_WSBEiJ_G0031196
 protein coding gene Chr7:29735965-29752397 (-)



Homology
more
  • Human Ortholog
    CD22, CD22 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD22, CD22 molecule
  • Synonyms
    SIGLEC-2, SIGLEC2
  • Links
    NCBI Gene ID: 933
    neXtProt AC: NX_P20273
    UniProt: P20273

  • Chr Location
    19q13.12; chr19:35319261-35347361 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 17 alleles in 15 genetic backgrounds
    7 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    48
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12483 NCBI Gene Model | MGI Sequence Detail 14939 C57BL/6J ±  kb
    transcript NR_102722 RefSeq | MGI Sequence Detail 4169 ZRU/MplStud  
    polypeptide P35329 UniProt | EBI | MGI Sequence Detail 868 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12060, MGD-MRK-12066, MGD-MRK-1839
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 90
    • Earliest
      J:6945 Symington FW, et al., Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics. 1982;16(5):381-91
    • Latest
      J:351182 McGettigan SE, et al., Secreted IgM modulates IL-10 expression in B cells. Nat Commun. 2024 Jan 5;15(1):324
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory