Cd27 MGI Mouse Gene Detail - MGI:88326

Symbol

Cd27
Name

CD27 antigen
Synonyms

Cd27, S152, Tnfrsf7, Tp55

Feature Type

protein coding gene
IDs

MGI:88326
NCBI Gene: 21940
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:125209585-125213973 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.32 cM
Mapping Data

3 experiments

SNPs within 2kb

137 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88326	protein coding gene	Chr6:125209583-125214014 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031293	protein coding gene	Chr6:128573572-128577949 (-)
A/J	MGP_AJ_G0031263	protein coding gene	Chr6:123718567-123722974 (-)
AKR/J	MGP_AKRJ_G0031191	protein coding gene	Chr6:127098586-127102941 (-)
BALB/cJ	MGP_BALBcJ_G0031271	protein coding gene	Chr6:123315947-123320299 (-)
C3H/HeJ	MGP_C3HHeJ_G0030994	protein coding gene	Chr6:127167498-127171849 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031727	protein coding gene	Chr6:131962700-131967079 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028876	protein coding gene	Chr6:120928764-120933203 (-)
CAST/EiJ	MGP_CASTEiJ_G0030375	protein coding gene	Chr6:127374726-127380902 (-)
CBA/J	MGP_CBAJ_G0030955	protein coding gene	Chr6:137009190-137013544 (-)
DBA/2J	MGP_DBA2J_G0031111	protein coding gene	Chr6:122650455-122654817 (-)
FVB/NJ	MGP_FVBNJ_G0031061	protein coding gene	Chr6:121563781-121568136 (-)
LP/J	MGP_LPJ_G0031191	protein coding gene	Chr6:128731653-128736003 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031099	protein coding gene	Chr6:141040636-141044996 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031762	protein coding gene	Chr6:127000349-127004727 (-)
PWK/PhJ	MGP_PWKPhJ_G0030090	protein coding gene	Chr6:120894340-120898776 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029919	protein coding gene	Chr6:125074932-125079808 (-)
WSB/EiJ	MGP_WSBEiJ_G0030460	protein coding gene	Chr6:127368414-127372804 (-)

Human Ortholog

CD27, CD27 molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD27, CD27 molecule
Synonyms

S152, S152. LPFS2, T14, TNFRSF7, Tp55
Links

HGNC:11922

NCBI Gene ID: 939

neXtProt AC: NX_P26842

UniProt: P26842
Chr Location

12p13.31; chr12:6443892-6451718 (+) GRCh38

MGI Vertebrate Homology

Cd27 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD27
Gene Tree

Cd27

Diseases

1 with human CD27 associations

				Human Disease	Mouse Models
				lymphoproliferative syndrome 2 IDs lymphoproliferative syndrome 2 DOID:0060708 ICD10CM:D47.9 OMIM:615122

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
56 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

8
Gene trapped

1
Targeted

7
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have a normal phenotype. However, T-cell development immune responses are abnormal.

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All GO Annotations

30
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

47
cDNA Data

20
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

59
RefSeq

14
UniProt

4
CCDS

CCDS39638.1, CCDS39639.1, CCDS71839.1

Ensembl

ENSMUSG00000030336 (Evidence)
NCBI Gene

21940

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030336	Ensembl Gene Model \| MGI Sequence Detail	4389	C57BL/6J	± kb
transcript	ENSMUST00000032486	Ensembl \| MGI Sequence Detail	1559	Not Applicable
polypeptide	ENSMUSP00000032486	Ensembl \| MGI Sequence Detail	250	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001963 CD27 molecule

(term hierarchy)
InterPro Domains

IPR053126 CD27 antigen receptor

IPR001368 TNFR/NGFR cysteine-rich region

IPR022328 Tumour necrosis factor receptor 7

IPR034000 Tumour necrosis factor receptor 7, N-terminal
GlyGen

P41272 2 sites

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All nucleic 30

Genomic 8

cDNA 20

Primer pair 2

Microarray probesets 4

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MGD-MRK-1844

Summaries

All 111

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 56
Earliest

J:4937 Gravestein LA, et al., Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur J Immunol. 1993 Apr;23(4):943-50
Latest

J:350581 Englebert K, et al., The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis. Cell Rep. 2024 Feb 20;43(3):113824

TSS for Cd27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2017	Chr6:125214057-125214064 (-)	-88 bp
Tssr63275	Chr6:125213959-125213988 (-)	-1 bp
Tssr63274	Chr6:125213937-125213956 (-)	26 bp
Tssr63273	Chr6:125213917-125213934 (-)	47 bp
Tssr63272	Chr6:125213886-125213897 (-)	81 bp
Tssr63271	Chr6:125213801-125213817 (-)	164 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24