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Cd37 Gene Detail
Summary
  • Symbol
    Cd37
  • Name
    CD37 antigen
  • Synonyms
    Tspan26
  • Feature Type
    protein coding gene
  • IDs
    MGI:88330
    NCBI Gene: 12493
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44883056-44888539 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.20 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88330
 protein coding gene Chr7:44883056-44888701 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032211
 protein coding gene Chr7:45476868-45482353 (-)
A/J MGP_AJ_G0032190
 protein coding gene Chr7:44608062-44613583 (-)
AKR/J MGP_AKRJ_G0032126
 protein coding gene Chr7:45838795-45844261 (-)
BALB/cJ MGP_BALBcJ_G0032202
 protein coding gene Chr7:44607712-44613221 (-)
C3H/HeJ MGP_C3HHeJ_G0031918
 protein coding gene Chr7:46331231-46336713 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032694
 protein coding gene Chr7:47741892-47747363 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029708
 protein coding gene Chr7:47170910-47176425 (-)
CAST/EiJ MGP_CASTEiJ_G0031246
 protein coding gene Chr7:37730153-37735666 (-)
CBA/J MGP_CBAJ_G0031882
 protein coding gene Chr7:49312044-49317514 (-)
DBA/2J MGP_DBA2J_G0032040
 protein coding gene Chr7:44281498-44287014 (-)
FVB/NJ MGP_FVBNJ_G0031991
 protein coding gene Chr7:44057092-44062557 (-)
LP/J MGP_LPJ_G0032118
 protein coding gene Chr7:46159247-46164743 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032028
 protein coding gene Chr7:48021681-48027164 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032710
 protein coding gene Chr7:45059778-45065313 (-)
PWK/PhJ MGP_PWKPhJ_G0030969
 protein coding gene Chr7:37647383-37653145 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030806
 protein coding gene Chr7:33072416-33079194 (-)
WSB/EiJ MGP_WSBEiJ_G0031363
 protein coding gene Chr7:45552796-45558308 (-)



Homology
more
  • Human Ortholog
    CD37, CD37 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD37, CD37 molecule
  • Synonyms
    GP52-40, TSPAN26
  • Links
    NCBI Gene ID: 951
    neXtProt AC: NX_P11049
    UniProt: P11049

  • Chr Location
    19q13.33; chr19:49335171-49343335 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced levels of IgG1 immunoglobulins and impaired antibody response to T cell dependent antigens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    1
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030798 Ensembl Gene Model | MGI Sequence Detail 5484 C57BL/6J ±  kb
    transcript ENSMUST00000033063 Ensembl | MGI Sequence Detail 1268 Not Applicable  
    polypeptide ENSMUSP00000033063 Ensembl | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 3
      cDNA 48

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1850
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:12638 Wright MD, et al., Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication. Int Immunol. 1993 Feb;5(2):209-16
    • Latest
      J:328898 Peeters R, et al., Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37. Nat Commun. 2022 Sep 13;13(1):5371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory