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Cd3e Gene Detail
Summary
  • Symbol
    Cd3e
  • Name
    CD3 antigen, epsilon polypeptide
  • Synonyms
    CD3, CD3epsilon, T3e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88332
    NCBI Gene: 12501
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44910038-44920925 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    437 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88332
 protein coding gene Chr9:44910033-44920961 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034726
 protein coding gene Chr9:43535066-43546331 (-)
A/J MGP_AJ_G0034707
 protein coding gene Chr9:42317507-42328633 (-)
AKR/J MGP_AKRJ_G0034634
 protein coding gene Chr9:43192849-43205071 (-)
BALB/cJ MGP_BALBcJ_G0034698
 protein coding gene Chr9:42051264-42062148 (-)
C3H/HeJ MGP_C3HHeJ_G0034409
 protein coding gene Chr9:43640789-43651772 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035219
 protein coding gene Chr9:44815479-44826326 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032134
 protein coding gene Chr9:41872724-41883898 (-)
CAST/EiJ MGP_CASTEiJ_G0033731
 protein coding gene Chr9:43506159-43518606 (-)
CBA/J MGP_CBAJ_G0034381
 protein coding gene Chr9:46452668-46466790 (-)
DBA/2J MGP_DBA2J_G0034540
 protein coding gene Chr9:42212685-42223583 (-)
FVB/NJ MGP_FVBNJ_G0034481
 protein coding gene Chr9:41467662-41478587 (-)
LP/J MGP_LPJ_G0034621
 protein coding gene Chr9:43831834-43844800 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034525
 protein coding gene Chr9:48285272-48296145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035240
 protein coding gene Chr9:43111636-43122520 (-)
PWK/PhJ MGP_PWKPhJ_G0033436
 protein coding gene Chr9:42094985-42106120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033272
 protein coding gene Chr9:43405367-43416617 (-)
WSB/EiJ MGP_WSBEiJ_G0033844
 protein coding gene Chr9:43139759-43150652 (-)



Homology
more
  • Human Ortholog
    CD3E, CD3 epsilon subunit of T-cell receptor complex
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD3E, CD3 epsilon subunit of T-cell receptor complex
  • Synonyms
    CD3epsilon, IMD18, T3E, TCRE
  • Links
    NCBI Gene ID: 916
    neXtProt AC: NX_P07766
    UniProt: P07766

  • Chr Location
    11q23.3; chr11:118304730-118316175 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD3E associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 7 alleles in 8 genetic backgrounds
    19 phenotypes from multigenic genotypes
    192 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous null for this mutation lack peripherial T cells and have a block of thymocyte development at the DN3 stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    29
  • cDNA Data
    21
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032093 Ensembl Gene Model | MGI Sequence Detail 10888 C57BL/6J ±  kb
    transcript ENSMUST00000102832 Ensembl | MGI Sequence Detail 1462 Not Applicable  
    polypeptide ENSMUSP00000099896 Ensembl | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 10
      cDNA 25
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14697, MGD-MRK-1853, MGI:2143086
    References
    more
    • Summaries
      All 354
      Developmental Gene Expression 60
      Diseases 1
      Gene Ontology 35
      Phenotypes 192
    • Earliest
      J:8304 Gold DP, et al., Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex [published erratum appears in Nature 1986 Dec 18-31;324(6098):702]. Nature. 1986 May 22-28;321(6068):431-4
    • Latest
      J:359311 Lin F, et al., Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Cell. 2024 Nov 2;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory