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Cd3g Gene Detail
Summary
  • Symbol
    Cd3g
  • Name
    CD3 antigen, gamma polypeptide
  • Synonyms
    Ctg-3, Ctg3, T3g
  • Feature Type
    protein coding gene
  • IDs
    MGI:88333
    NCBI Gene: 12502
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44880870-44891729 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88333
 protein coding gene Chr9:44880870-44891729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034724
 protein coding gene Chr9:43503274-43515331 (-)
A/J MGP_AJ_G0034705
 protein coding gene Chr9:42282592-42293573 (-)
AKR/J MGP_AKRJ_G0034632
 protein coding gene Chr9:43160553-43171253 (-)
BALB/cJ MGP_BALBcJ_G0034696
 protein coding gene Chr9:42021262-42032259 (-)
C3H/HeJ MGP_C3HHeJ_G0034407
 protein coding gene Chr9:43611468-43622148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035217
 protein coding gene Chr9:44785235-44796455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032132
 protein coding gene Chr9:41843990-41855115 (-)
CAST/EiJ MGP_CASTEiJ_G0033729
 protein coding gene Chr9:43472307-43485804 (-)
CBA/J MGP_CBAJ_G0034379
 protein coding gene Chr9:46418155-46428945 (-)
DBA/2J MGP_DBA2J_G0034538
 protein coding gene Chr9:42177203-42188007 (-)
FVB/NJ MGP_FVBNJ_G0034479
 protein coding gene Chr9:41439687-41450326 (-)
LP/J MGP_LPJ_G0034619
 protein coding gene Chr9:43801786-43812746 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034523
 protein coding gene Chr9:48253367-48266238 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035238
 protein coding gene Chr9:43081524-43092203 (-)
PWK/PhJ MGP_PWKPhJ_G0033434
 protein coding gene Chr9:42064372-42075981 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033270
 protein coding gene Chr9:43372134-43384199 (-)
WSB/EiJ MGP_WSBEiJ_G0033842
 protein coding gene Chr9:43109358-43120034 (-)



Homology
more
  • Human Ortholog
    CD3G, CD3 gamma subunit of T-cell receptor complex
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD3G, CD3 gamma subunit of T-cell receptor complex
  • Synonyms
    CD3-GAMMA, CD3GAMMA, IMD17, T3G
  • Links
    NCBI Gene ID: 917
    neXtProt AC: NX_P09693
    UniProt: P09693

  • Chr Location
    11q23.3; chr11:118344344-118355161 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD3G associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased thymocyte number and T cell response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    4
  • cDNA Data
    29
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12502 NCBI Gene Model | MGI Sequence Detail 10860 C57BL/6J ±  kb
    transcript NM_009850 RefSeq | MGI Sequence Detail 1019 C57BL/6  
    polypeptide P11942 UniProt | EBI | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 9
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14698, MGD-MRK-1854, MGD-MRK-2212, MGD-MRK-2213
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:8651 Gold DP, et al., The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1664-8
    • Latest
      J:340980 Chora AF, et al., Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via gammadelta T cells and IL-17-promoted stress erythropoiesis. Immunity. 2023 Mar 14;56(3):592-605.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory