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Cd4 Gene Detail
Summary
  • Symbol
    Cd4
  • Name
    CD4 antigen
  • Synonyms
    L3T4, Ly-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88335
    NCBI Gene: 12504
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124841655-124865184 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    645 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    6
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0031275
 protein coding gene Chr6:128175215-128201064 (-)
A/J MGP_AJ_G0031245
 protein coding gene Chr6:123350831-123399534 (-)
AKR/J MGP_AKRJ_G0031173
 protein coding gene Chr6:126716376-126767792 (-)
BALB/cJ MGP_BALBcJ_G0031253
 protein coding gene Chr6:122951280-123000174 (-)
C3H/HeJ MGP_C3HHeJ_G0030976
 protein coding gene Chr6:126765836-126816990 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031709
 protein coding gene Chr6:131555640-131579161 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028859
 protein coding gene Chr6:120560733-120584382 (-)
CAST/EiJ MGP_CASTEiJ_G0030357
 protein coding gene Chr6:126972854-126997851 (-)
CBA/J MGP_CBAJ_G0030937
 protein coding gene Chr6:136586635-136641341 (-)
DBA/2J MGP_DBA2J_G0031093
 protein coding gene Chr6:122277926-122328994 (-)
FVB/NJ MGP_FVBNJ_G0031043
 protein coding gene Chr6:121181258-121204968 (-)
LP/J MGP_LPJ_G0031173
 protein coding gene Chr6:128342209-128368722 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031081
 protein coding gene Chr6:140646584-140670114 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031744
 protein coding gene Chr6:126609060-126632474 (-)
PWK/PhJ MGP_PWKPhJ_G0030072
 protein coding gene Chr6:120509096-120533619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029901
 protein coding gene Chr6:124693735-124717341 (-)
WSB/EiJ MGP_WSBEiJ_G0030442
 protein coding gene Chr6:126970685-126994213 (-)



Homology
more
  • Human Ortholog
    CD4, CD4 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD4, CD4 molecule
  • Synonyms
    CD4mut, IMD79, Leu-3, OKT4D, T4
  • Links
    NCBI Gene ID: 920
    neXtProt AC: NX_P01730
    UniProt: P01730

  • Chr Location
    12p13.31; chr12:6786858-6820799 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 11 alleles in 16 genetic backgrounds
    37 phenotypes from multigenic genotypes
    398 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    62
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    58
  • cDNA Data
    35
  • Literature Summary
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023274 Ensembl Gene Model | MGI Sequence Detail 23530 C57BL/6J ±  kb
    transcript ENSMUST00000024044 Ensembl | MGI Sequence Detail 3108 Not Applicable  
    polypeptide ENSMUSP00000024044 Ensembl | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 15
      cDNA 35
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11981, MGD-MRK-1858
    References
    more
    • Summaries
      All 726
      Developmental Gene Expression 56
      Diseases 2
      Gene Ontology 62
      Phenotypes 398
    • Earliest
      J:5358 Snell GD, et al., Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11
    • Latest
      J:359567 Al-Omari AA, et al., Modi-2 a vaccine stimulating CD4 responses to homocitrullinated self epitopes as therapy for solid cancers. NPJ Vaccines. 2024 Nov 27;9(1):236
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory