Cd7 MGI Mouse Gene Detail - MGI:88344

Symbol

Cd7
Name

CD7 antigen

Feature Type

protein coding gene
IDs

MGI:88344
NCBI Gene: 12516
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:120927573-120930244 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 84.85 cM
Mapping Data

3 experiments

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88344	protein coding gene	Chr11:120927573-120930304 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019535	protein coding gene	Chr11:125566904-125569575 (-)
A/J	MGP_AJ_G0019502	protein coding gene	Chr11:119959682-119962353 (-)
AKR/J	MGP_AKRJ_G0019472	protein coding gene	Chr11:123584959-123587628 (-)
BALB/cJ	MGP_BALBcJ_G0019477	protein coding gene	Chr11:120327632-120330301 (-)
C3H/HeJ	MGP_C3HHeJ_G0019283	protein coding gene	Chr11:123913523-123916194 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019926	protein coding gene	Chr11:129368136-129370805 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017551	protein coding gene	Chr11:116942239-116945044 (-)
CAST/EiJ	MGP_CASTEiJ_G0018837	protein coding gene	Chr11:125416481-125419172 (-)
CBA/J	MGP_CBAJ_G0019254	protein coding gene	Chr11:134399120-134401791 (-)
DBA/2J	MGP_DBA2J_G0019367	protein coding gene	Chr11:119328470-119331141 (-)
FVB/NJ	MGP_FVBNJ_G0019358	protein coding gene	Chr11:119046057-119048754 (-)
LP/J	MGP_LPJ_G0019438	protein coding gene	Chr11:125847432-125850127 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019391	protein coding gene	Chr11:133219184-133221855 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019965	protein coding gene	Chr11:124264018-124266687 (-)
PWK/PhJ	MGP_PWKPhJ_G0018603	protein coding gene	Chr11:120768483-120771186 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018395	protein coding gene	Chr11:124024062-124026737 (-)
WSB/EiJ	MGP_WSBEiJ_G0018890	protein coding gene	Chr11:124242517-124245212 (-)

Human Ortholog

CD7, CD7 molecule

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD7, CD7 molecule
Synonyms

GP40, LEU-9, Tp40, TP41
Links

HGNC:1695

NCBI Gene ID: 924

neXtProt AC: NX_P09564

UniProt: P09564
Chr Location

17q25.3; chr17:82314868-82317608 (-) GRCh38

MGI Vertebrate Homology

Cd7 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CD7
Gene Tree

Cd7

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Phenotype Summary

7 phenotypes from 3 alleles in 4 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

7
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in a 60% increase of CD4+CD8+ thymocytes at 3 months of age.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

45
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS25764.1

Ensembl

ENSMUSG00000025163 (Evidence)
NCBI Gene

12516

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025163	Ensembl Gene Model \| MGI Sequence Detail	2672	C57BL/6J	± kb
transcript	ENSMUST00000026159	Ensembl \| MGI Sequence Detail	982	Not Applicable
polypeptide	ENSMUSP00000026159	Ensembl \| MGI Sequence Detail	210	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001836 CD7 molecule

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR039090 T-cell antigen CD7
GlyGen

P50283 3 sites

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All nucleic 20

Genomic 6

cDNA 13

Primer pair 1

Microarray probesets 3

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MGD-MRK-1870

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 16
Earliest

J:4522 Yoshikawa K, et al., Isolation and characterization of mouse CD7 cDNA. Immunogenetics. 1993;37(2):114-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112438	Chr11:120930226-120930289 (-)	-14 bp
Tssr112437	Chr11:120930207-120930218 (-)	31 bp
Tssr112436	Chr11:120929132-120929137 (-)	1,109 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24