Cd72 MGI Mouse Gene Detail - MGI:88345

Symbol

Cd72
Name

CD72 antigen
Synonyms

Ly-19, Ly-32, Lyb-2, Ly-m19

Feature Type

protein coding gene
IDs

MGI:88345
NCBI Gene: 12517
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:43447724-43454708 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.04 cM
Mapping Data

40 experiments

SNPs within 2kb

341 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88345	protein coding gene	Chr4:43446462-43454708 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028206	protein coding gene	Chr4:41557608-41565762 (-)
A/J	MGP_AJ_G0028162	protein coding gene	Chr4:40084894-40093050 (-)
AKR/J	MGP_AKRJ_G0028114	protein coding gene	Chr4:40996639-41004962 (-)
BALB/cJ	MGP_BALBcJ_G0028182	protein coding gene	Chr4:40174600-40182756 (-)
C3H/HeJ	MGP_C3HHeJ_G0027904	protein coding gene	Chr4:41621687-41629843 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028623	protein coding gene	Chr4:43118629-43126795 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025935	protein coding gene	Chr4:37536014-37544358 (-)
CAST/EiJ	MGP_CASTEiJ_G0027344	protein coding gene	Chr4:41126182-41134437 (-)
CBA/J	MGP_CBAJ_G0027870	protein coding gene	Chr4:44423316-44431473 (-)
DBA/2J	MGP_DBA2J_G0028019	protein coding gene	Chr4:39996890-40005047 (-)
FVB/NJ	MGP_FVBNJ_G0027986	protein coding gene	Chr4:39215090-39223521 (-)
LP/J	MGP_LPJ_G0028118	protein coding gene	Chr4:41614475-41622641 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028010	protein coding gene	Chr4:47687931-47696254 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028659	protein coding gene	Chr4:41189712-41197878 (-)
PWK/PhJ	MGP_PWKPhJ_G0027070	protein coding gene	Chr4:40039410-40047594 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026896	protein coding gene	Chr4:40755810-40763991 (-)
WSB/EiJ	MGP_WSBEiJ_G0027424	protein coding gene	Chr4:41094367-41102505 (-)

Human Ortholog

CD72, CD72 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD72, CD72 molecule
Synonyms

CD72b, LYB2
Links

HGNC:1696

NCBI Gene ID: 971

neXtProt AC: NX_P21854

UniProt: P21854
Chr Location

9p13.3; chr9:35609982-35646857 (-) GRCh38

MGI Vertebrate Homology

Cd72 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD72
Gene Tree

Cd72

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Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
26 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically and radiation induced

1
Endonuclease-mediated

3
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Cd72
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in impaired B cell development and delayed maturation, resulting in reduced numbers of mature B cells and an expansion of pre-B cells. Mice have fewer peripheral mature B-2 cells and more B-1 cells. B cells are hyperproliferative in response to stimuli.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

5
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

81
RefSeq

26
UniProt

8
CCDS

CCDS38740.1, CCDS51164.1, CCDS51165.1, CCDS51166.1

Ensembl

ENSMUSG00000028459 (Evidence)
NCBI Gene

12517

			Length	Strain/Species	Flank
genomic	12517	NCBI Gene Model \| MGI Sequence Detail	6985	C57BL/6J	± kb
transcript	NM_001419976	RefSeq \| MGI Sequence Detail	1590	ZRU/MplStud
polypeptide	P21855	UniProt \| EBI \| MGI Sequence Detail	354	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000001287 CD72 molecule

(term hierarchy)
PDB

5B1R
InterPro Domains

IPR039689 B-cell differentiation antigen CD72

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily
GlyGen

P21855 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

cDNA 16

Microarray probesets 3

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MGD-MRK-11957, MGD-MRK-11973, MGD-MRK-12012, MGD-MRK-12054, MGD-MRK-1871

Summaries

All 88

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 17
Earliest

J:12065 Sato H, et al., A new alloantigen expressed on B cells: the Lyb-2 system. Immunogenetics. 1976;3:565-572
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cd72:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41420	Chr4:43454913-43454928 (-)	-213 bp
Tssr41419	Chr4:43454876-43454900 (-)	-180 bp
Tssr41418	Chr4:43454600-43454635 (-)	90 bp
Tssr41417	Chr4:43454582-43454587 (-)	123 bp
Tssr41416	Chr4:43454564-43454576 (-)	138 bp
Tssr41415	Chr4:43454537-43454547 (-)	166 bp
Tssr41414	Chr4:43452589-43452613 (-)	2,107 bp
Tssr41413	Chr4:43452551-43452563 (-)	2,151 bp
Tssr41412	Chr4:43452518-43452543 (-)	2,177 bp
Tssr41411	Chr4:43452457-43452489 (-)	2,235 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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