Cd8a MGI Mouse Gene Detail - MGI:88346

Symbol

Cd8a
Name

CD8 subunit alpha
Synonyms

Ly-2, Ly-35, Ly-B, Lyt-2

Feature Type

protein coding gene
IDs

MGI:88346
NCBI Gene: 12525
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr6:71350411-71356155 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.14 cM, cytoband C
Mapping Data

67 experiments

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88346	protein coding gene	Chr6:71350411-71356157 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030857	protein coding gene	Chr6:71849732-71854529 (+)
A/J	MGP_AJ_G0030827	protein coding gene	Chr6:69084573-69088632 (+)
AKR/J	MGP_AKRJ_G0030756	protein coding gene	Chr6:71066698-71070779 (+)
BALB/cJ	MGP_BALBcJ_G0030838	protein coding gene	Chr6:69116950-69121178 (+)
C3H/HeJ	MGP_C3HHeJ_G0030874	protein coding gene	Chr6:113176288-113180358 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031296	protein coding gene	Chr6:73740391-73745169 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028485	protein coding gene	Chr6:68266010-68271500 (+)
CAST/EiJ	MGP_CASTEiJ_G0029946	protein coding gene	Chr6:70930223-70936553 (+)
CBA/J	MGP_CBAJ_G0030525	protein coding gene	Chr6:76666456-76676852 (+)
DBA/2J	MGP_DBA2J_G0030677	protein coding gene	Chr6:68460370-68464455 (+)
FVB/NJ	MGP_FVBNJ_G0030630	protein coding gene	Chr6:67826447-67830601 (+)
LP/J	MGP_LPJ_G0030756	protein coding gene	Chr6:71775585-71779972 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030665	protein coding gene	Chr6:80157305-80161377 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031322	protein coding gene	Chr6:70914042-70918096 (+)
PWK/PhJ	MGP_PWKPhJ_G0029662	protein coding gene	Chr6:67328964-67335237 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029490	protein coding gene	Chr6:69619207-69623244 (+)
WSB/EiJ	MGP_WSBEiJ_G0030028	protein coding gene	Chr6:71252705-71257892 (+)

Human Ortholog

CD8A, CD8 subunit alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD8A, CD8 subunit alpha
Synonyms

CD8, CD8alpha, IMD116, Leu2, p32
Links

HGNC:1706

NCBI Gene ID: 925

neXtProt AC: NX_P01732

UniProt: P01732
Chr Location

2p11.2; chr2:86784605-86808396 (-) GRCh38

MGI Vertebrate Homology

Cd8a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD8A
Gene Tree

Cd8a

Diseases

1 with human CD8A associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 7 alleles in 11 genetic backgrounds
28 phenotypes from multigenic genotypes
367 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (ENU)

2
Endonuclease-mediated

10
Spontaneous

1
Targeted

8
Transgenic

1
Genomic Mutations

1 involving Cd8a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available

Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.

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All GO Annotations

31
GO References

45

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

48
cDNA Data

37
Literature Summary

20

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cd8a

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All Sequences

52
RefSeq

4
UniProt

8
CCDS

CCDS39507.1, CCDS51806.1

Ensembl

ENSMUSG00000053977 (Evidence)
NCBI Gene

12525

			Length	Strain/Species	Flank
genomic	12525	NCBI Gene Model \| MGI Sequence Detail	5745	C57BL/6J	± kb
transcript	NM_001081110	RefSeq \| MGI Sequence Detail	3130	Not Specified
polypeptide	P01731	UniProt \| EBI \| MGI Sequence Detail	247	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000001084 T-cell surface glycoprotein CD8 alpha chain

(term hierarchy)
PDB

1BQH, 1NEZ, 2ARJ, 2ATP, 3B9K, 3DMM
InterPro Domains

IPR015468 CD8 alpha subunit

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

P01731 3 sites

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All nucleic 59

Genomic 18

cDNA 38

Primer pair 2

Other 1

Microarray probesets 5

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MGD-MRK-11958, MGD-MRK-11976, MGD-MRK-12074, MGD-MRK-1872, MGI:2141733

Summaries

All 632

Developmental Gene Expression 20

Gene Ontology 45

Phenotypes 367
Earliest

J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
Latest

J:354623 Ran L, et al., The transcription regulator ID3 maintains tumor-specific memory CD8(+) T cells in draining lymph nodes during tumorigenesis. Cell Rep. 2024 Sep 24;43(9):114690

TSS for Cd8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57018	Chr6:71349632-71349648 (+)	-771 bp
Tssr57019	Chr6:71350360-71350363 (+)	-49 bp
Tssr57020	Chr6:71350384-71350449 (+)	6 bp
Tssr57021	Chr6:71350464-71350474 (+)	58 bp
Tssr57022	Chr6:71350478-71350568 (+)	112 bp
Tssr57023	Chr6:71350581-71350595 (+)	177 bp
Tssr57024	Chr6:71351303-71351317 (+)	899 bp
Tssr57025	Chr6:71351502-71351526 (+)	1,103 bp
Tssr57026	Chr6:71351561-71351570 (+)	1,155 bp
Tssr57027	Chr6:71354285-71354301 (+)	3,882 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24