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Cdc25c Gene Detail
Summary
  • Symbol
    Cdc25c
  • Name
    cell division cycle 25C
  • Synonyms
    Cdc25
  • Feature Type
    protein coding gene
  • IDs
    MGI:88350
    NCBI Gene: 12532
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34866046-34884586 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    657 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88350
 protein coding gene Chr18:34866046-34884644 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024248
 protein coding gene Chr18:32967147-32986076 (-)
A/J MGP_AJ_G0024214
 protein coding gene Chr18:31847488-31865990 (-)
AKR/J MGP_AKRJ_G0024183
 protein coding gene Chr18:32767167-32786470 (-)
BALB/cJ MGP_BALBcJ_G0024214
 protein coding gene Chr18:31907154-31926094 (-)
C3H/HeJ MGP_C3HHeJ_G0023982
 protein coding gene Chr18:32778319-32798217 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024656
 protein coding gene Chr18:34237741-34256039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022097
 protein coding gene Chr18:31991306-32009261 (-)
CAST/EiJ MGP_CASTEiJ_G0023457
 protein coding gene Chr18:32732077-32750340 (-)
CBA/J MGP_CBAJ_G0023950
 protein coding gene Chr18:35166004-35184273 (-)
DBA/2J MGP_DBA2J_G0024082
 protein coding gene Chr18:31504561-31523289 (-)
FVB/NJ MGP_FVBNJ_G0024048
 protein coding gene Chr18:31188738-31207150 (-)
LP/J MGP_LPJ_G0024163
 protein coding gene Chr18:33047959-33066225 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024076
 protein coding gene Chr18:36426076-36447097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024704
 protein coding gene Chr18:32581396-32600841 (-)
PWK/PhJ MGP_PWKPhJ_G0023200
 protein coding gene Chr18:31706062-31725961 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023009
 protein coding gene Chr18:32858588-32879283 (-)
WSB/EiJ MGP_WSBEiJ_G0023520
 protein coding gene Chr18:32510387-32530131 (-)



Homology
more
  • Human Ortholog
    CDC25C, cell division cycle 25C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC25C, cell division cycle 25C
  • Synonyms
    CDC25, PPP1R60
  • Links
    NCBI Gene ID: 995
    neXtProt AC: NX_P30307
    UniProt: P30307

  • Chr Location
    5q31.2; chr5:138285265-138338355 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CDC25C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    4 images
    11 phenotype references
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    34
  • cDNA Data
    42
  • Literature Summary
    18
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044201 Ensembl Gene Model | MGI Sequence Detail 18541 C57BL/6J ±  kb
transcript ENSMUST00000060710 Ensembl | MGI Sequence Detail 1945 Not Applicable  
polypeptide ENSMUSP00000055427 Ensembl | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 43
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1876, MGD-MRK-1877
References
more
  • Summaries
    All 67
    Developmental Gene Expression 18
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:1241 Sartor H, et al., Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. Genomics. 1992 Jul;13(3):911-2
  • Latest
    J:332876 Zhou X, et al., Downregulation of CDC25C in NPCs Disturbed Cortical Neurogenesis. Int J Mol Sci. 2023 Jan 12;24(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory