Cdh3 MGI Mouse Gene Detail - MGI:88356 - cadherin 3

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Cdh3 Gene Detail

Symbol

Cdh3
Name

cadherin 3
Synonyms

Cadp, Pcad, P-cadherin

Feature Type

protein coding gene
IDs

MGI:88356
NCBI Gene: 12560
Alliance

gene page
Transcription Start Sites

2 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr8:107237484-107283543 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.16 cM
Mapping Data

6 experiments

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SNPs within 2kb

1375 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_88356	protein coding gene	Chr8:107237484-107283929 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034084	protein coding gene	Chr8:108854209-108903122 (+)
A/J	MGP_AJ_G0034065	protein coding gene	Chr8:104515373-104561923 (+)
AKR/J	MGP_AKRJ_G0033991	protein coding gene	Chr8:107549339-107608581 (+)
BALB/cJ	MGP_BALBcJ_G0034058	protein coding gene	Chr8:104706249-104752689 (+)
C3H/HeJ	MGP_C3HHeJ_G0033770	protein coding gene	Chr8:108288467-108338976 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034578	protein coding gene	Chr8:112862485-112912265 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031520	protein coding gene	Chr8:97634585-97681154 (+)
CAST/EiJ	MGP_CASTEiJ_G0033096	protein coding gene	Chr8:107790916-107845918 (+)
CBA/J	MGP_CBAJ_G0033743	protein coding gene	Chr8:116490071-116545160 (+)
DBA/2J	MGP_DBA2J_G0033898	protein coding gene	Chr8:103854235-103902536 (+)
FVB/NJ	MGP_FVBNJ_G0033843	protein coding gene	Chr8:102790200-102836288 (+)
LP/J	MGP_LPJ_G0033989	protein coding gene	Chr8:109064803-109114708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033887	protein coding gene	Chr8:119657331-119710452 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034596	protein coding gene	Chr8:107485741-107534202 (+)
PWK/PhJ	MGP_PWKPhJ_G0032797	protein coding gene	Chr8:103261648-103308652 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032638	protein coding gene	Chr8:106202539-106256905 (+)
WSB/EiJ	MGP_WSBEiJ_G0033212	protein coding gene	Chr8:108186136-108237333 (+)

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Human Ortholog

CDH3, cadherin 3

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDH3, cadherin 3
Synonyms

CDHP, HJMD, PCAD
Links

HGNC:1762

NCBI Gene ID: 1001

neXtProt AC: NX_P22223

UniProt: P22223
Chr Location

16q22.1; chr16:68636189-68733771 (+) GRCh38

MGI Vertebrate Homology

Cdh3 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CDH3
Gene Tree

Cdh3

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Diseases

2 with human CDH3 associations

				Human Disease	Mouse Models
				congenital hypotrichosis with juvenile macular dystrophy IDs congenital hypotrichosis with juvenile macular dystrophy DOID:0110711 OMIM:601553
				ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome IDs ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome DOID:0111649 OMIM:225280 ORDO:1897

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

4
Gene trapped

18
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Cdh3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in precocious development of mammary glands in virgin 10-week old females. Aged virgin females (24 weeks) exhibit alveolar hyperplasia, ductal dysplasia, and extensive lymphocyte infiltration of the mammary glands.

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All GO Annotations

43
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1117
Tissues

312
cDNA Data

64
Literature Summary

113

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdh3

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS22637.1

Ensembl

ENSMUSG00000061048 (Evidence)
NCBI Gene

12560

Representative Sequences				Length	Strain/Species	Flank
	genomic	12560	NCBI Gene Model \| MGI Sequence Detail	46060	C57BL/6J	± kb
	transcript	NM_001037809	RefSeq \| MGI Sequence Detail	4037	ZRU/MplStud
	polypeptide	P10287	UniProt \| EBI \| MGI Sequence Detail	822	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005245 cadherin-3

(term hierarchy)
PDB

4NQQ
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR000233 Cadherin, Y-type LIR-motif

IPR027397 Catenin binding domain superfamily
GlyGen

P10287 3 sites, 1 O-linked glycan (1 site)

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All nucleic 85

Genomic 10

cDNA 64

Primer pair 7

Other 4

Microarray probesets 4

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MGD-MRK-13170, MGD-MRK-1723, MGD-MRK-1883, MGI:2142516

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Summaries

All 178

Developmental Gene Expression 113

Gene Ontology 8

Phenotypes 17
Earliest

J:31206 Nose A, et al., A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol. 1986 Dec;103(6 Pt 2):2649-58
Latest

J:352885 Beaulac HJ, et al., Localization of cadherins in the postnatal cochlear epithelium and their relation to space formation. Dev Dyn. 2024 Aug;253(8):771-780

TSS for Cdh3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79250	Chr8:107237485-107237556 (+)	37 bp
Tssr79251	Chr8:107282629-107282633 (+)	45,147 bp

Cdh3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bwq3	Chr8, 61.66 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 8, Es22 (43.2 cM) and Cdh3 (53.3 cM) both show differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTL Wg3 (45 cM) mapsnear Es22 and diabesity QTL Bwq3 (56 cM) maps near Chd3.
Wg3	Chr8, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 8, Es22 (43.2 cM) and Cdh3 (53.3 cM) both show differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTL Wg3 (45 cM) mapsnear Es22 and diabesity QTL Bwq3 (56 cM) maps near Chd3.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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