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Cdk4 Gene Detail
Summary
  • Symbol
    Cdk4
  • Name
    cyclin dependent kinase 4
  • Synonyms
    Crk3, p34PSK-J3/cdk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88357
    NCBI Gene: 12567
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:126899404-126903157 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88357
 protein coding gene Chr10:126899403-126903789 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017804
 protein coding gene Chr10:130639526-130644674 (+)
A/J MGP_AJ_G0017779
 protein coding gene Chr10:125407477-125412078 (+)
AKR/J MGP_AKRJ_G0017742
 protein coding gene Chr10:129120230-129124518 (+)
BALB/cJ MGP_BALBcJ_G0017743
 protein coding gene Chr10:125814971-125819993 (+)
C3H/HeJ MGP_C3HHeJ_G0017567
 protein coding gene Chr10:129254208-129259072 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018198
 protein coding gene Chr10:135068811-135073197 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015878
 protein coding gene Chr10:119431160-119435573 (+)
CAST/EiJ MGP_CASTEiJ_G0017127
 protein coding gene Chr10:129907853-129912261 (+)
CBA/J MGP_CBAJ_G0017536
 protein coding gene Chr10:140486297-140491751 (+)
DBA/2J MGP_DBA2J_G0017642
 protein coding gene Chr10:124496998-124501384 (+)
FVB/NJ MGP_FVBNJ_G0017637
 protein coding gene Chr10:123446700-123450099 (+)
LP/J MGP_LPJ_G0017716
 protein coding gene Chr10:131210462-131214670 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017665
 protein coding gene Chr10:143223114-143232240 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018238
 protein coding gene Chr10:129175280-129179665 (+)
PWK/PhJ MGP_PWKPhJ_G0016912
 protein coding gene Chr10:124686360-124691843 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016704
 protein coding gene Chr10:128201786-128206178 (+)
WSB/EiJ MGP_WSBEiJ_G0017188
 protein coding gene Chr10:129400286-129406485 (+)



Homology
more
  • Human Ortholog
    CDK4, cyclin dependent kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK4, cyclin dependent kinase 4
  • Synonyms
    CMM3, PSK-J3
  • Links
    NCBI Gene ID: 1019
    neXtProt AC: NX_P11802
    UniProt: P11802

  • Chr Location
    12q14.1; chr12:57747727-57756013 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdk4 mouse models; 9 with human CDK4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 6 alleles in 7 genetic backgrounds
    67 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1050
  • Tissues
    225
  • cDNA Data
    393
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12567 NCBI Gene Model | MGI Sequence Detail 3754 C57BL/6J ±  kb
    transcript NM_009870 RefSeq | MGI Sequence Detail 1420 C57BL/6  
    polypeptide P30285 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 404
      cDNA 395
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1884, MGD-MRK-2147, MGI:88504
    References
    more
    • Summaries
      All 327
      Developmental Gene Expression 109
      Diseases 3
      Gene Ontology 41
      Phenotypes 113
    • Earliest
      J:2804 Matsushime H, et al., Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell. 1992 Oct 16;71(2):323-34
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory