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Cel Gene Detail
Summary
  • Symbol
    Cel
  • Name
    carboxyl ester lipase
  • Synonyms
    1810036E18Rik, BAL
  • Feature Type
    protein coding gene
  • IDs
    MGI:88374
    NCBI Gene: 12613
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28445831-28453415 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88374
 protein coding gene Chr2:28445807-28453415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025526
 protein coding gene Chr2:26617533-26625138 (-)
A/J MGP_AJ_G0025503
 protein coding gene Chr2:25608792-25616335 (-)
AKR/J MGP_AKRJ_G0025473
 protein coding gene Chr2:26455681-26463291 (-)
BALB/cJ MGP_BALBcJ_G0025499
 protein coding gene Chr2:25728380-25735990 (-)
C3H/HeJ MGP_C3HHeJ_G0025260
 protein coding gene Chr2:26380240-26387848 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025943
 protein coding gene Chr2:27516809-27524332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023353
 protein coding gene Chr2:24421577-24429083 (-)
CAST/EiJ MGP_CASTEiJ_G0024723
 protein coding gene Chr2:26282374-26292659 (-)
CBA/J MGP_CBAJ_G0025238
 protein coding gene Chr2:28447622-28455221 (-)
DBA/2J MGP_DBA2J_G0025371
 protein coding gene Chr2:25416632-25424240 (-)
FVB/NJ MGP_FVBNJ_G0025333
 protein coding gene Chr2:25202915-25210523 (-)
LP/J MGP_LPJ_G0025457
 protein coding gene Chr2:26572685-26580289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025364
 protein coding gene Chr2:28450659-28458267 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026002
 protein coding gene Chr2:26369497-26377105 (-)
PWK/PhJ MGP_PWKPhJ_G0024470
 protein coding gene Chr2:25223094-25230752 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024270
 protein coding gene Chr2:26501649-26509324 (-)
WSB/EiJ MGP_WSBEiJ_G0024792
 protein coding gene Chr2:26502607-26510203 (-)



Homology
more
  • Human Ortholog
    CEL, carboxyl ester lipase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEL, carboxyl ester lipase
  • Synonyms
    BAL, BSDL, BSSL, CEase, CELL, FAP, FAPP, LIPA, MODY8
  • Links
    NCBI Gene ID: 1056
    UniProt: P19835

  • Chr Location
    9q34.13; chr9:133061981-133071861 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CEL associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced cholesteryl ester absorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    141
  • cDNA Data
    292
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12613 NCBI Gene Model | MGI Sequence Detail 7585 C57BL/6J ±  kb
transcript NM_009885 RefSeq | MGI Sequence Detail 2080 ZRU/MplStud  
polypeptide Q64285 UniProt | EBI | MGI Sequence Detail 599 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 301
    Genomic 4
    cDNA 294
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1918, MGI:1925734
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:4122 Wen PZ, et al., Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse. Genomics. 1993 Feb;15(2):458-60
  • Latest
    J:337474 Cobo I, et al., NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory