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Cenpb Gene Detail
Summary
  • Symbol
    Cenpb
  • Name
    centromere protein B
  • Feature Type
    protein coding gene
  • IDs
    MGI:88376
    NCBI Gene: 12616
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131019209-131021974 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88376
 protein coding gene Chr2:131017102-131021987 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026525
 protein coding gene Chr2:134687925-134692723 (-)
A/J MGP_AJ_G0026489
 protein coding gene Chr2:129221669-129226554 (-)
AKR/J MGP_AKRJ_G0026464
 protein coding gene Chr2:132954952-132959837 (-)
BALB/cJ MGP_BALBcJ_G0026501
 protein coding gene Chr2:129607773-129613141 (-)
C3H/HeJ MGP_C3HHeJ_G0026244
 protein coding gene Chr2:133389232-133394117 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026946
 protein coding gene Chr2:138824460-138829345 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024323
 protein coding gene Chr2:123966374-123971306 (-)
CAST/EiJ MGP_CASTEiJ_G0025705
 protein coding gene Chr2:133671945-133676849 (-)
CBA/J MGP_CBAJ_G0026224
 protein coding gene Chr2:143993637-144001368 (-)
DBA/2J MGP_DBA2J_G0026358
 protein coding gene Chr2:128611889-128616818 (-)
FVB/NJ MGP_FVBNJ_G0026322
 protein coding gene Chr2:127241612-127246497 (-)
LP/J MGP_LPJ_G0026463
 protein coding gene Chr2:134917313-134922198 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026342
 protein coding gene Chr2:147809421-147814307 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027001
 protein coding gene Chr2:132910851-132916271 (-)
PWK/PhJ MGP_PWKPhJ_G0025441
 protein coding gene Chr2:128181730-128186892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025243
 protein coding gene Chr2:132062234-132067087 (-)
WSB/EiJ MGP_WSBEiJ_G0025779
 protein coding gene Chr2:133832948-133839242 (-)



Homology
more
  • Human Ortholog
    CENPB, centromere protein B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPB, centromere protein B
  • Links
    NCBI Gene ID: 1059
    neXtProt AC: NX_P07199
    UniProt: P07199

  • Chr Location
    20p13; chr20:3783851-3786740 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CENPB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display decreased body weight, small testis, oligospermia, and an age- and background-dependent reduction in female reproductive competence associated with abnormalities in uterus morphology, metral environment, gestational length, and parturition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    35
  • cDNA Data
    137
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12616 NCBI Gene Model | MGI Sequence Detail 2766 C57BL/6J ±  kb
    transcript NM_007682 RefSeq | MGI Sequence Detail 2766 ZRU/MplStud  
    polypeptide P27790 UniProt | EBI | MGI Sequence Detail 599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 147
      Genomic 9
      cDNA 137
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1940
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:352179 Gambogi CW, et al., Centromere innovations within a mouse species. Sci Adv. 2023 Nov 17;9(46):eadi5764
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory