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Ces1g Gene Detail
Summary
  • Symbol
    Ces1g
  • Name
    carboxylesterase 1G
  • Synonyms
    Ces-1, Ces1, Ses-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88378
    NCBI Gene: 12623
  • Member of
    Ces1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94028997-94063837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 45.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1393 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88378
 protein coding gene Chr8:94028997-94063936 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033946
 protein coding gene Chr8:94673300-94715712 (-)
A/J MGP_AJ_G0033929
 protein coding gene Chr8:90971133-91007252 (-)
AKR/J MGP_AKRJ_G0033855
 protein coding gene Chr8:93471970-93511020 (-)
BALB/cJ MGP_BALBcJ_G0033921
 protein coding gene Chr8:91074156-91113046 (-)
C3H/HeJ MGP_C3HHeJ_G0033631
 protein coding gene Chr8:94177471-94215139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034442
 protein coding gene Chr8:98109721-98160630 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031383
 protein coding gene Chr8:84812548-84844334 (-)
CAST/EiJ MGP_CASTEiJ_G0032963
 protein coding gene Chr8:93743591-93787859 (-)
CBA/J MGP_CBAJ_G0033607
 protein coding gene Chr8:101389581-101438987 (-)
DBA/2J MGP_DBA2J_G0033761
 protein coding gene Chr8:90457239-90492209 (-)
FVB/NJ MGP_FVBNJ_G0033708
 protein coding gene Chr8:89412863-89447973 (-)
LP/J MGP_LPJ_G0033853
 protein coding gene Chr8:94808195-94843528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033750
 protein coding gene Chr8:103708230-103750637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034460
 protein coding gene Chr8:93614187-93654762 (-)
PWK/PhJ MGP_PWKPhJ_G0032665
 protein coding gene Chr8:89804511-89835064 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032502
 protein coding gene Chr8:92459978-92498527 (-)
WSB/EiJ MGP_WSBEiJ_G0033075
 protein coding gene Chr8:94054759-94097408 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES1, carboxylesterase 1
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833337 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CES1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased lipogenesis accompanied with insulin resistance, hyperinsulinemia, and decreased energy expenditure; as a result, they become obese even on a standard chow diet and develop hepatic steatosis and hyperlipidemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    9
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12623 NCBI Gene Model | MGI Sequence Detail 34841 C57BL/6J ±  kb
    transcript NM_021456 RefSeq | MGI Sequence Detail 2289 ZRU/MplStud  
    polypeptide Q8VCC2 UniProt | EBI | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14364, MGD-MRK-1943, MGD-MRK-1944
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:14958 Becker-Follmann J, et al., Assignment of human monocyte/macrophage serine esterase 1 (HMSE1) to human Chromosome 16q13-q22.1 and of its homologue to the proximal esterase cluster on mouse Chromosome 8. Cytogenet Cell Genet. 1991;58:1997 (Abstr.)
    • Latest
      J:286897 Xu J, et al., Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice. Sci Rep. 2017 Dec 19;7(1):17845
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory