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F9 Gene Detail
Summary
  • Symbol
    F9
  • Name
    coagulation factor IX
  • Synonyms
    Cf-9, Cf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:88384
    NCBI Gene: 14071
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:59044824-59076119 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 33.50 cM, cytoband A6-A7
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    736 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88384
 protein coding gene ChrX:59044675-59076120 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035755
 protein coding gene ChrX:55352996-55384199 (+)
A/J MGP_AJ_G0035737
 protein coding gene ChrX:55560567-55592367 (+)
AKR/J MGP_AKRJ_G0035657
 protein coding gene ChrX:57044272-57080673 (+)
BALB/cJ MGP_BALBcJ_G0035724
 protein coding gene ChrX:54927696-54959163 (+)
C3H/HeJ MGP_C3HHeJ_G0035426
 protein coding gene ChrX:55907903-55939458 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036253
 protein coding gene ChrX:56830646-56871124 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033105
 protein coding gene ChrX:55385238-55417683 (+)
CAST/EiJ MGP_CASTEiJ_G0034719
 protein coding gene ChrX:41680766-41714873 (+)
CBA/J MGP_CBAJ_G0035401
 protein coding gene ChrX:58505803-58543786 (+)
DBA/2J MGP_DBA2J_G0035555
 protein coding gene ChrX:55136577-55168091 (+)
FVB/NJ MGP_FVBNJ_G0035505
 protein coding gene ChrX:54680851-54711720 (+)
LP/J MGP_LPJ_G0035643
 protein coding gene ChrX:55945464-55976642 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035541
 protein coding gene ChrX:60095530-60128368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036269
 protein coding gene ChrX:55385967-55417984 (+)
PWK/PhJ MGP_PWKPhJ_G0034414
 protein coding gene ChrX:39863167-39895156 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034259
 protein coding gene ChrX:42509978-42541193 (+)
WSB/EiJ MGP_WSBEiJ_G0034862
 protein coding gene ChrX:54886884-54919077 (+)



Homology
more
  • Human Ortholog
    F9, coagulation factor IX
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F9, coagulation factor IX
  • Synonyms
    F9 p22, FIX, HEMB, P19, PTC, THPH8
  • Links
    NCBI Gene ID: 2158
    neXtProt AC: NX_P00740
    UniProt: P00740

  • Chr Location
    Xq27.1; chrX:139530739-139563459 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with F9 mouse models; 3 with human F9 associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 8 alleles in 7 genetic backgrounds
    1 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male hemizygotes for targeted null mutations are subject to fatal blood loss after tail snipping, and some affected males spontaneously die from umbilical cord bleeding. Carrier females show reduced levels of factor IX.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    18
  • cDNA Data
    15
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031138 Ensembl Gene Model | MGI Sequence Detail 31296 C57BL/6J ±  kb
    transcript ENSMUST00000033477 Ensembl | MGI Sequence Detail 2734 Not Applicable  
    polypeptide ENSMUSP00000033477 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007303 coagulation factor IX
      (term hierarchy)
    • EC
      3.4.21.22
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
      IPR050442 Peptidase S1 family, coagulation factors
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    • GlyGen
      P16294 9 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 18
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1950, MGD-MRK-1956, MGI:2147999
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 5
      Diseases 4
      Gene Ontology 5
      Phenotypes 46
    • Earliest
      J:8649 Avner P, et al., Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1629-33
    • Latest
      J:357791 Han W, et al., Characteristics of FXa-storing platelets in hemophilia B mice and the influence of alcohol on the platelets. Sci Rep. 2023 Oct 1;13(1):16488
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory