Chga MGI Mouse Gene Detail - MGI:88394

Symbol

Chga
Name

chromogranin A
Synonyms

ChrA

Feature Type

protein coding gene
IDs

MGI:88394
NCBI Gene: 12652
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:102521228-102531287 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.66 cM
Mapping Data

5 experiments

SNPs within 2kb

330 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88394	protein coding gene	Chr12:102521200-102531287 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020033	protein coding gene	Chr12:104191300-104201779 (+)
A/J	MGP_AJ_G0019989	protein coding gene	Chr12:100193263-100203075 (+)
AKR/J	MGP_AKRJ_G0019965	protein coding gene	Chr12:103037681-103047733 (+)
BALB/cJ	MGP_BALBcJ_G0019975	protein coding gene	Chr12:100543441-100553501 (+)
C3H/HeJ	MGP_C3HHeJ_G0019777	protein coding gene	Chr12:103495510-103505338 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020424	protein coding gene	Chr12:107436652-107449020 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018037	protein coding gene	Chr12:97206499-97217292 (+)
CAST/EiJ	MGP_CASTEiJ_G0019323	protein coding gene	Chr12:98334434-98345958 (+)
CBA/J	MGP_CBAJ_G0019749	protein coding gene	Chr12:111424494-111437517 (+)
DBA/2J	MGP_DBA2J_G0019860	protein coding gene	Chr12:99708539-99718373 (+)
FVB/NJ	MGP_FVBNJ_G0019849	protein coding gene	Chr12:98437286-98447584 (+)
LP/J	MGP_LPJ_G0019936	protein coding gene	Chr12:104042235-104052282 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019889	protein coding gene	Chr12:114898823-114908869 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020453	protein coding gene	Chr12:102534327-102545743 (+)
PWK/PhJ	MGP_PWKPhJ_G0019086	protein coding gene	Chr12:94265209-94275414 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018882	protein coding gene	Chr12:96719026-96729800 (+)
WSB/EiJ	MGP_WSBEiJ_G0019377	protein coding gene	Chr12:103427097-103438063 (+)

Human Ortholog

CHGA, chromogranin A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHGA, chromogranin A
Synonyms

CGA, PHE5, PHES
Links

HGNC:1929

NCBI Gene ID: 1113

neXtProt AC: NX_P10645

UniProt: P10645
Chr Location

14q32.12; chr14:92922664-92935285 (+) GRCh38

MGI Vertebrate Homology

Chga stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHGA
Gene Tree

Chga

Diseases

4 with human CHGA associations

				Human Disease	Mouse Models
				end stage renal disease IDs end stage renal disease DOID:783
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

1 involving Chga
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes and heterozygotes for one allele display hypertension, abnormal plasma and adrenal adrenaline and noradrenaline levels and, in homozygotes, partial embryonic lethality. Homozygotes for a second allele only have elevated urinary adrenaline, noradrenaline and dopamine levels.

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All GO Annotations

48
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

910
Tissues

99
cDNA Data

43
Literature Summary

139

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CHGA

Xenbase chga

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS26120.1

Ensembl

ENSMUSG00000021194 (Evidence)
NCBI Gene

12652

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021194	Ensembl Gene Model \| MGI Sequence Detail	10060	C57BL/6J	± kb
transcript	ENSMUST00000021610	Ensembl \| MGI Sequence Detail	1883	Not Applicable
polypeptide	ENSMUSP00000021610	Ensembl \| MGI Sequence Detail	463	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005421 chromogranin-A

(term hierarchy)
PDB

5DMK
InterPro Domains

IPR001819 Chromogranin A/B

IPR001990 Chromogranin A/B/C

IPR018054 Chromogranin, conserved site
GlyGen

P26339 1 site

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All nucleic 53

Genomic 2

cDNA 44

Primer pair 4

Other 3

Microarray probesets 3

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MGD-MRK-1969

Summaries

All 218

Developmental Gene Expression 139

Gene Ontology 9

Phenotypes 33
Earliest

J:19363 Modi WS, et al., The human chromogranin A gene: chromosome assignment and RFLP analysis. Am J Hum Genet. 1989 Nov;45(5):814-8
Latest

J:353482 Ortiz JA, et al., Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461

TSS for Chga:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114764	Chr12:102520488-102520518 (+)	-725 bp
Tssr114765	Chr12:102521225-102521243 (+)	6 bp
Tssr114766	Chr12:102528086-102528099 (+)	6,865 bp
Tssr114767	Chr12:102528852-102528887 (+)	7,642 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24