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Chrm1 Gene Detail
Summary
  • Symbol
    Chrm1
  • Name
    cholinergic receptor, muscarinic 1, CNS
  • Synonyms
    AW495047, Chrm-1, M1, M1R, muscarinic acetylcholine receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88396
    NCBI Gene: 12669
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8641369-8660970 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88396
 protein coding gene Chr19:8641153-8660970 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024802
 protein coding gene Chr19:5929084-5949023 (+)
A/J MGP_AJ_G0024770
 protein coding gene Chr19:5615370-5635022 (+)
AKR/J MGP_AKRJ_G0024745
 protein coding gene Chr19:5697471-5717233 (+)
BALB/cJ MGP_BALBcJ_G0024770
 protein coding gene Chr19:5716728-5736663 (+)
C3H/HeJ MGP_C3HHeJ_G0024536
 protein coding gene Chr19:5782930-5803803 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025217
 protein coding gene Chr19:6043250-6063468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022646
 protein coding gene Chr19:5853466-5873214 (+)
CAST/EiJ MGP_CASTEiJ_G0024009
 protein coding gene Chr19:5427580-5448662 (+)
CBA/J MGP_CBAJ_G0024510
 protein coding gene Chr19:6158317-6180203 (+)
DBA/2J MGP_DBA2J_G0024637
 protein coding gene Chr19:5436469-5456391 (+)
FVB/NJ MGP_FVBNJ_G0024604
 protein coding gene Chr19:5517088-5536924 (+)
LP/J MGP_LPJ_G0024724
 protein coding gene Chr19:5817974-5837806 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024631
 protein coding gene Chr19:6033648-6054431 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025266
 protein coding gene Chr19:5737386-5757156 (+)
PWK/PhJ MGP_PWKPhJ_G0023754
 protein coding gene Chr19:5105046-5125354 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023559
 protein coding gene Chr19:5345895-5365592 (+)
WSB/EiJ MGP_WSBEiJ_G0024071
 protein coding gene Chr19:5706648-5726560 (+)



Homology
more
  • Human Ortholog
    CHRM1, cholinergic receptor muscarinic 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRM1, cholinergic receptor muscarinic 1
  • Synonyms
    HM1, M1, M1R
  • Links
    NCBI Gene ID: 1128
    neXtProt AC: NX_P11229
    UniProt: P11229

  • Chr Location
    11q12.3; chr11:62908679-62921878 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CHRM1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit resistance to pilocarpine-induced seizures, selective memory deficits, elevated dopaminergic transmission in the striatum, and increased spontaneous and amphetamine-induced locomotion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    64
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12669 NCBI Gene Model | MGI Sequence Detail 19602 C57BL/6J ±  kb
    transcript NM_001112697 RefSeq | MGI Sequence Detail 6301 C57BL/6  
    polypeptide P12657 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1974, MGD-MRK-1978, MGI:3528183
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 97
    • Earliest
      J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
    • Latest
      J:354353 Gu Z, et al., Cholinergic-Sensitive Theta Oscillations in Memory Encoding in Mice. J Neurosci. 2024 Mar 20;44(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory