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Chrm2 Gene Detail
Summary
  • Symbol
    Chrm2
  • Name
    cholinergic receptor, muscarinic 2, cardiac
  • Synonyms
    AChR M2, Chrm-2, M2, muscarinic acetylcholine receptor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88397
    NCBI Gene: 243764
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:36365019-36505349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3689 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88397
 protein coding gene Chr6:36364928-36505573 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030573
 protein coding gene Chr6:34546157-34685729 (+)
A/J MGP_AJ_G0030546
 protein coding gene Chr6:33059976-33205290 (+)
AKR/J MGP_AKRJ_G0030473
 protein coding gene Chr6:34136221-34269236 (+)
BALB/cJ MGP_BALBcJ_G0030556
 protein coding gene Chr6:33258367-33395225 (+)
C3H/HeJ MGP_C3HHeJ_G0030269
 protein coding gene Chr6:34138620-34278305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031010
 protein coding gene Chr6:35421013-35565644 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028222
 protein coding gene Chr6:31034366-31164834 (+)
CAST/EiJ MGP_CASTEiJ_G0029671
 protein coding gene Chr6:33943322-34090209 (+)
CBA/J MGP_CBAJ_G0030247
 protein coding gene Chr6:36809883-36962983 (+)
DBA/2J MGP_DBA2J_G0030391
 protein coding gene Chr6:32908025-33045184 (+)
FVB/NJ MGP_FVBNJ_G0030345
 protein coding gene Chr6:32708619-32848285 (+)
LP/J MGP_LPJ_G0030478
 protein coding gene Chr6:34669034-34806686 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030381
 protein coding gene Chr6:39173996-39324089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031040
 protein coding gene Chr6:34046452-34179341 (+)
PWK/PhJ MGP_PWKPhJ_G0029385
 protein coding gene Chr6:32512137-32647371 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029221
 protein coding gene Chr6:33725436-33860748 (+)
WSB/EiJ MGP_WSBEiJ_G0029747
 protein coding gene Chr6:33974945-34114345 (+)



Homology
more
  • Human Ortholog
    CHRM2, cholinergic receptor muscarinic 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRM2, cholinergic receptor muscarinic 2
  • Synonyms
    HM2
  • Links
    NCBI Gene ID: 1129
    neXtProt AC: NX_P08172
    UniProt: P08172

  • Chr Location
    7q33; chr7:136868652-137020255 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human CHRM2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have slightly decreased body weight (5%) compared to wild-type animals and are resistant to the tremorogenic, analgesic, and hypothermic responses to oxotremorine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    65
  • cDNA Data
    4
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045613 Ensembl Gene Model | MGI Sequence Detail 140331 C57BL/6J ±  kb
    transcript ENSMUST00000172278 Ensembl | MGI Sequence Detail 5676 Not Applicable  
    polypeptide ENSMUSP00000130874 Ensembl | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1975, MGD-MRK-1979
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 76
    • Earliest
      J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
    • Latest
      J:348397 Fasciani I, et al., The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions. PLoS Biol. 2024 Apr;22(4):e3002582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory